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A Note on Some Examples of Chiral High-Performance Liquid Chromatographic Resolution in the Pharmaceutical Industry

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Recent Advances in Chiral Separations

Part of the book series: Chromatographic Society Symposium Series ((CSSS))

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Abstract

Examples of the methods by which enantiomers may be resolved chromatographically using either preliminary derivatisation with a chiral reagent, direct separation using a chiral mobile phase, or by direct separation using a chiral stationary phase (CSP) are outlined. These methods are illustrated by reference to chiral resolutions of compounds of interest to Glaxo Group Research Limited.

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References

  1. P. Marfey, Carlsberg Res. Commun., 49: 591 (1984).

    Article  CAS  Google Scholar 

  2. T. Takeuchi, H. Asai and D. Ishii, J. Chromatogr, 357: 409–415 (1986).

    Article  CAS  Google Scholar 

  3. W. H. Pirkle and J. M. Finn, J. Org. Chem, 46: 2935–2938 (1981).

    Google Scholar 

  4. W. H. Pirkle and C. J. Welch, J. Org. Chem, 49: 138–140 (1984).

    Article  CAS  Google Scholar 

  5. G. Schill, I. W. Wainer and S. A. Barkan, J. Liq. Chromatogr., 9: 641–666 (1986).

    Article  CAS  Google Scholar 

  6. G. Schill, I. W. Wainer and S. A. Barkan, J. Chromatogr, 365: 73–88 (1986).

    Article  CAS  PubMed  Google Scholar 

  7. Y. Okamoto, R Aburatani, Y. Kaida and K. Hatada, Chem. Lett, 1125–1128 (1988).

    Google Scholar 

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© 1991 Plenum Press, New York

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Collicott, R.J. (1991). A Note on Some Examples of Chiral High-Performance Liquid Chromatographic Resolution in the Pharmaceutical Industry. In: Stevenson, D., Wilson, I.D. (eds) Recent Advances in Chiral Separations. Chromatographic Society Symposium Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8282-9_4

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  • DOI: https://doi.org/10.1007/978-1-4684-8282-9_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-8284-3

  • Online ISBN: 978-1-4684-8282-9

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