Summary
One of the major problems facing the analyst in chiral high-performance liquid chromatography (HPLC) is that of selecting an appropriate chiral stationary phase (CSP) for a given analysis. Here an attempt is made to address the problem by proposing a simple algorithm for use in CSP selection, based upon Wainer’s classification of the five main types of CSP.
The prospect of using computer-assisted molecular modelling (CAMM) to assist in this area has aroused much interest, and several case histories of such investigations are described. These case histories highlight not only the power of CAMM in modelling diastereoisomeric interaction complexes, but also the associated problems which can arise.
In addition, suggestions for other approaches to the design of new CSPs are made, including work based upon both reciprocity of interaction and the development of new families of CSPs.
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References
I. W. Wainer, “Practical Guide to Selection and Use of HPLC Chiral Stationary Phases”, J. T. Baker Inc., Phillipsburg, NJ (1988).
G. Blaschke, H.-P. Kraft and H. Markgraf, Chem. Ber., 113: 2318–2322 (1980).
I. W. Waffler, Trends in Analytical Chem., 6: 125–134 (1987).
D. M. McDaniel and B. G. Snider, J. Chromatogr., 404: 123–132 (1987).
J. Hermansson and M. Eriksson, J. Liquid Chromatogr., 9: 621–639 (1986).
I. W. Wainer and T. D. Doyle, J. Chromatogr., 284: 117–124 (1984).
I. W. Wainer, T. D. Doyle, K. H. Donn and J. R Powell, J. Chromatogr., 306: 405–411 (1984).
D. W. Armstrong, T. J. Ward, R. D. Armstrong and T. E. Beesley, Science, 232: 11321135 (1986).
J. N. Akanya, S. M. Hitchen and D. R. Taylor, Chromatographia, 16: 224–227 (1982).
J. N Akanya and D. R. Taylor, J. Liquid Chromtogr., 10: 805–817 (1987).
G. Bridger, PhD Thesis, UMIST (1987).
K. B. Lipkowitz, D. A. Demeter, R Zegarra, R. M. Larter and T. Darden, J. Comput. Chem., 9: 63–78 (1988).
K. B. Lipkowitz, D. A. Demeter, C. A. Parish, J. M. Landwer and T. Darden, J. Comput. Chem, 8: 753–760 (1987).
K. B. Lipkowitz, D. A. Demeter, C. A. Parish and T. Darden, Anal. Chem., 59: 1731–1733 (1987).
U. Norinder and E. G. Sundholm, J. Liquid Chromatogr., 10: 2825–2844 (1987).
S. Topiol, M. Sabio, J. Moroz and W. B. Caldwell, J. Am. Chem. Soc., 110: 8367–8376 (1988).
S. Topiol and M. Sabio, J. Chromatogr., 461: 129–148 (1989).
W. H. Pirkle and T. C. Pochapsky, J. Am. Chem Soc., 109: 5975–5982 (1987).
W. H. Pirkle and R Dappen, J. Chromatogr., 404: 107–115 (1987).
R Daeppen, V. R. Meyer and H. Arm, J. Chromatogr., 464: 39–47 (1989).
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© 1991 Plenum Press, New York
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Taylor, D.R. (1991). Is There a Rational Basis for the Selection and/or Design of Chiral Stationary Phases for High-Performance Liquid Chromatography?. In: Stevenson, D., Wilson, I.D. (eds) Recent Advances in Chiral Separations. Chromatographic Society Symposium Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8282-9_2
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DOI: https://doi.org/10.1007/978-1-4684-8282-9_2
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