Abstract
Since Schill et al. first reported chiral ion-pair high-performance liquid chromatography (HPLC) in 1981 [1], much work has been carried out using this technique [2,3]. However, apart from the use of L-quinine to resolve the racemates of some acidic drugs [5], it has been used almost exclusively for the enantiomeric resolution of β-blockers. This is due to this class of compound having the necessry features for chiral recognition by the acidic chiral ion-pairing reagents used, D-10-camphorsulphonic acid and N-benzyloxycarbonyl-glycyl-proline. The chiral centre is very close to the basic centre of the molecule and also contains a functional group capable of hydrogen-bonding interaction with the carbonyl groups on the acidic chiral ion-pair reagents [3].
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References
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V. de Biasi, M. B. Evans and W. J. Lough, manuscript in preparation.
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© 1991 Plenum Press, New York
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de Biasi, V., Evans, M.B., Lough, W.J. (1991). A Note on Chiral Ion-Pair Chromatography of Novel Basic Antihypertensive Agents. In: Stevenson, D., Wilson, I.D. (eds) Recent Advances in Chiral Separations. Chromatographic Society Symposium Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8282-9_13
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DOI: https://doi.org/10.1007/978-1-4684-8282-9_13
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