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An Evaluation of Some Chiral Stationary Phases for the Separation of β-Blocker Drugs

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Recent Advances in Chiral Separations

Part of the book series: Chromatographic Society Symposium Series ((CSSS))

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Summary

Three different chiral stationary phases have been evaluated for their ability to resolve racemic propranolol and other β-blocker drugs. Cyclobond 1 was not successful in separating underivatised propranolol. αl-Acid glycoprotein successfully separated the drugs atenolol, alprenolol, metoprolol, oxprenolol, practolol, pronethalol and propranolol into their enantiomers. Separations for propranolol, pronethalol, oxprenolol, metoprolol and alprenolol as their 1- or 2-naphthamide derivatives were achieved on a covalent 3,5-dinitrobenzoyl phenylglycine phase. The derivatisation reaction was rapid and quantitive.

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Author information

Authors and Affiliations

  1. Robens Institute of Health and Safety, University of Surrey, Guildford, Surrey, GU2 5XH, UK

    G. A. Kingston & D. Stevenson

Authors
  1. G. A. Kingston
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  2. D. Stevenson
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Editor information

Editors and Affiliations

  1. Robens Institute of Health and Safety, University of Surrey, Guildford, Surrey, UK

    D. Stevenson

  2. ICI Pharmaceuticals, Macclesfield, Cheshire, UK

    I. D. Wilson

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© 1991 Plenum Press, New York

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Kingston, G.A., Stevenson, D. (1991). An Evaluation of Some Chiral Stationary Phases for the Separation of β-Blocker Drugs. In: Stevenson, D., Wilson, I.D. (eds) Recent Advances in Chiral Separations. Chromatographic Society Symposium Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8282-9_10

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  • DOI: https://doi.org/10.1007/978-1-4684-8282-9_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-8284-3

  • Online ISBN: 978-1-4684-8282-9

  • eBook Packages: Springer Book Archive

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