Catabolism in Acute Renal Failure: Importance of Glucocorticoids and Lysosomal Enzymes

  • August Heidland
  • Roland M. Schaefer
  • Joachim Weipert
  • Ekkehart Heidbreder
  • Markus Teschner
  • Gernot Peter
  • Walter H. Horl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


Renal failure has been previously shown to be a catabolic event1–6. There is growing evidence for a certain role of proteolytic enzymes in the catabolism of acute uremia7–13 Thus, frank proteolytic activity has been demonstrated in ultrafiltrated plasma fractions, in the urine and bronchoalveolar-lavage (BAL) fluid14–15 The type of proteinases involved, is up to now not totally defined. There are some data, which indicate a participation of broad spectrum serine proteinases in the BAL-fluid and in the plasma of ureter-ligated rats16.


Acute Renal Failure Muscle Protein Cyanogen Bromide Leukocyte Elastase Muscle Protein Breakdown 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • August Heidland
    • 1
  • Roland M. Schaefer
    • 1
  • Joachim Weipert
    • 1
  • Ekkehart Heidbreder
    • 1
  • Markus Teschner
    • 1
  • Gernot Peter
    • 2
  • Walter H. Horl
    • 3
  1. 1.Department of MedicineUniversity of WurzburgGermany
  2. 2.Department of DermatologyUniversity of WurzburgGermany
  3. 3.Department of MedicineUniversity of FreiburgFreiburgGermany

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