Role of Endotoxin in Hepatorenal Syndrome

  • Giuseppe Passavanti
  • Pasquale Coratelli
  • Irene Munno
  • Donato Fumarola
  • Alberto Amerio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


It is known that patients affected by liver cirrhosis may develop functional renal failure induced by circulatory disorder of the kidney, likely due to active vasoconstriction with reduction of cortical perfusion (1), and characterized by reduced glomerular filtration rate with intact tubular function. In fact the urine sodium concentration in these patients is extremely low, usualy less than 10 milliequivalent per liter, and urine sediment is relatively unremarkable. This type of renal failure is called hepatorenal syndrome (HRS) and many factors have been considered in its pathogenesis, including activation of the renin — angiotensin system due to reduced “effective” blood volume (2,3,4), increase in sympathetic nervous system activity (5,6,7,8), alterations in the endogenous release of renal prostaglandins (9,10,11,12,13,14,15) and changes in the kallikrein-kinin system (16).


Hepatorenal Syndrome Hepatic Coma Limulus Amebocyte Lysate Progressive Renal Failure Renal Prostaglandin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Giuseppe Passavanti
    • 1
  • Pasquale Coratelli
    • 1
  • Irene Munno
    • 2
  • Donato Fumarola
    • 2
  • Alberto Amerio
    • 1
  1. 1.Institute of NephrologyUniversity of BariBariItaly
  2. 2.Institute of MicrobiologyUniversity of BariBariItaly

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