The Hepatorenal Syndrome (HRS)

  • Murray Epstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


Progressive oliguric renal failure commonly complicates the course of patients with advanced hepatic disease (1,2). While this condition has been designated by many names including “functional renal failure”, and “the renal failure of cirrhosis”, the more appealing albeit less specific term “hepatorenal syndrome” has been utilized commonly to describe this syndrome. For the purposes of this discussion, the hepatorenal syndrome may be defined as unexplained progressive renal failure occurring in patients with liver disease in the absence of clinical, laboratory, or anatomic evidence of other known causes of renal failure.


Cirrhotic Patient Sympathetic Nervous System Activity Hepatorenal Syndrome Renal Vasoconstriction Renal Hypoperfusion 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Murray Epstein
    • 1
  1. 1.Division of NephrologyUniversity of Miami School of Medicine and Veterans Administration Medical CenterMiamiUSA

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