Effects of Intravenous Infusion of Urographic Contrast Agents on Glomerular Filtration Rate, Serum Concentration and Urinary Excretion of Uric Acid in Subjects with Normal Renal Function

  • C. Jacobs
  • D. Nicolay
  • J. Grellet
  • Ph. Curet
  • A. Jardin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


The utilization of modern triiodinated radiocontrast agents for intravenous urography (IVU) is widely considered as a very safe procedure in patients free of currently well defined risk factors, amongst which the prominent ones are preexisting renal disease and diabetes mellitus complicated by deteriorated renal function (1,2,3). Whereas the incidence of nephrotoxicity accidents is extremely low in patients with no preexisting renal insufficiency, the risk of an acute, and sometimes definitive, deterioration of renal function following administration of radiocontrast agents has been evaluated as high as 90 % in insulin dependent diabetic patients with severe preexisting renal impairment (1).


Uric Acid Serum Uric Acid Normal Renal Function Intravenous Urography Serum Uric Acid Concentration 
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  1. 1.
    S. Harkonen and C. Kjellstrand, Contrast nephropathy, Am. J. Nephrol. 1:69 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    G. H. Mudge, Nephrotoxicity of urographie radiocontrast drugs, Kidney Int. 18: 540 (1980).Google Scholar
  3. 3.
    L. Byrd and R. L. Sherman, Radiocontrast induced acute renal failure. A clinical and pathophysiologic review, Medicine 58: 270 (1979).Google Scholar
  4. 4.
    G. H. Mudge, Uricosuric action of cholecystographic agents: a possible factor in nephrotoxicity, N. Engl. J. Med. 284:929 (1971).PubMedCrossRefGoogle Scholar
  5. 5.
    A. E. Postlethwaite and W. N. Kelley, Uricosuric effect of radiocontrast agents, Ann. Int. Med. 74:845 (1971).PubMedGoogle Scholar
  6. 6.
    S. Kumar, J. D. Hull, S. Lathi, A. J. Cohen and P. G. Pletka, Low incidence of renal failure after angiography, Arch. Int. Med. 141:1268 (1981).CrossRefGoogle Scholar
  7. 7.
    B. C. Cramer, P. S. Parfrey, T. A. Hutchinson, D. Baran, D. M. Melanson R. E. Ethier and J. F. Seely, Renal function following infusion of radiographic contrast material. A prospective controlled study, Arch. Int. Med. 145:87 (1985).Google Scholar
  8. 8.
    B. E. Van Zee, W. E. Hoy, T. E. Talley and J. R. Jaenike, Renal injury associated with intravenous urography in non diabetic and diabetic patients, Ann. Int. Med. 89:51 (1978).Google Scholar
  9. 9.
    J. L. Teruel, R. Marcen, J. M. Onaindia, A. Serrano, C. Quereda and J. Ortuno, Renal function impairment caused by intravenous urography, Arch. Int. Med. 141:1271 (1981).CrossRefGoogle Scholar
  10. 10.
    J. A. D’Elia, R. E. Gleason, M. Alday, C. Malarick, K. Godley, J. Warram, A. Kaldani and L. A. Weinrauch, Nephrotoxicity from angiographic contrast material, Am. J. Med. 72:719 (1982).PubMedCrossRefGoogle Scholar
  11. 11.
    L. B. Talner and A. J. Davidson, Effect of contrast media on renal excretion of PAH, Invest. Radiol. 3:301 (1968).PubMedCrossRefGoogle Scholar
  12. 12.
    S. M. Tadavarthy, W. Castaneda and K. Amplatz, Redistribution of renal blood flow caused by contrast media, Radiology 122: 343 (1977).Google Scholar
  13. 13.
    P. Schiantarelli, F. Peroni, P. Turone and G. Rosati, Effects of iodinated contrast media on erythrocytes, Invest. Radiol. 8:199 (1973).PubMedCrossRefGoogle Scholar
  14. 14.
    R. E. Berdon, R. H. Schwartz, J. Becker and D. H. Baker, Tamm-Horsfall proteinuria: its relationship to prolonged nephrogram in infants and children and to renal failure following intravenous urography in adults with multiple myeloma, Radiology 92: 714 (1969).Google Scholar
  15. 15.
    N. Milman and P. Gottlieb, Renal function after high-dose urography in patients with chronic renal insufficiency, Clin. Nephrol. 7:250 (1977).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • C. Jacobs
    • 1
  • D. Nicolay
    • 1
  • J. Grellet
    • 1
  • Ph. Curet
    • 1
  • A. Jardin
    • 1
  1. 1.Hôspital de La Pitiè 83Boulevard de l’HôspitalParisFrance

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