Skip to main content
SpringerLink
Log in

Contrast-Induced Acute Renal Failure

  • Chapter
Acute Renal Failure

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 212))

Abstract

Acute renal failure (ARF) can occur after radiologic procedures involving administration of contrast agents for angiography, intravenous urography (IVU), oral cholecystography, cholangiography and computerized tomography (CAT). However, the true incidence of this untoward effect is unknown.Large retrospective reviews, indicate that the incidence of contrast induced acute renal failure in the general population is low, being probably, greater for angiography (0.53%) than for IVU or CAT (0.15%) (1). In some series, the incidence of ARF after angiographic studies was as high as 13% (2–3). The greater incidence of renal complications following angiography may be the result of higher intrarenal concentration of contrast agent or of cholesterol embolization. These retrospective analysis, however, tend to underestimate the true incidence of this complication, since they include only the more serious cases requiring further medical attention but not the majority of cases with only mild and transitory rise in serum creatinine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Byrd, L., Sherman, R.L.: Radiocontrast-induced acute renal failure: A clinical and pathophysiologic review. Medicine 58: 270–279, 1979.

    Article  PubMed  CAS  Google Scholar 

  2. Older, R.A., Miller, J.P., Jackson, D.C., Johnsrude, I.S., Thompson, W.M.: Angiographically induced renal failure and its radiographic detection. Am. M. Roentgenol. 126: 1039–1045, 1976.

    CAS  Google Scholar 

  3. Swartz, R.D., Rubin, J.E., Leeming, B.W., Silva, P.: Renal failure following major angiography. Am. J. Med. 65: 31–37, 1978.

    Article  PubMed  CAS  Google Scholar 

  4. Van Zee, B.E., Hoy, W.E., Talley, T.E., Jaenike, J.R.: Renal injury associated with intravenous pyelography in nondiabetic and diabetic patients. Ann. Intern. Med. 89: 51–54, 1978.

    Google Scholar 

  5. Diaz-Buxo, J.A., Wagoner, R.D., Hattery, R.R., Palumbo, P.J.: Acute renal failure after excretory urography in diabetic patients. Ann. Intern. Med. 83: 155–158, 1975.

    PubMed  CAS  Google Scholar 

  6. Gelman, L.M., Rowe, J.W., Coggins, C.H.: Effects of an angiographic contrast agent on renal function. Cardiovasc. Med. 4: 313–320, 1979.

    Google Scholar 

  7. Eisenberger, R.L., Bank, W.D., Hedglock, M.W.: Renal failure after major angiography. Am. J. Med. 68: 43–46, 1979.

    Article  Google Scholar 

  8. D’elia, J., Alday, M., Gleason, R., Malarick, C., Clouse, M., Kaldany, A., Weinrauch, L.: Acute renal failure following angiography. Prospective study of 150 patients, preliminary results. Proc. Clin. Dial. Transplant Forum 8: 123–124, 1978.

    PubMed  Google Scholar 

  9. Cramer, R.C., Parfrey, P.S., Hutchinson, T.A., Baran, D., Melanson, D.M., Ethier, R.E., Seely, J.F.: Renal function following infusion of radiologic contrast material. A prospective controlled study. Arch. Intern. Med. 145: 87–89, 1985.

    Article  PubMed  CAS  Google Scholar 

  10. Kumar, S., Hull, J.D., Lathi, S., Cohen, A.J., Pletka, P.G.: Low incidence of renal failure after angiography. Arch. Int. Med. 141: 1268–1270, 1981.

    Article  CAS  Google Scholar 

  11. Shafi, T., Chou, S., Porush, J.G., Shapiro, W.B.: Infusion intravenous pyelography and renal function. Arch. Intern. Med. 138: 1218 1221, 1978.

    Google Scholar 

  12. Milman, N., Gottlieb, P.: Renal function after high-dose Urography in patients with chronic renal insufficiency. Clin. Nephrol. 7: 250254, 1977.

    Google Scholar 

  13. Dudzinski, P.J., Petrone, A.F., Persoff, V., Callaghan, E.E.: Acute renal failure following high dose excretory urography in dehydrated patients. J. Urol. 106: 619–621, 1971.

    PubMed  CAS  Google Scholar 

  14. Larson, T.S., Hudson, K., Mertz, J.I., Romero, J.C., Knox, F.G.: Renal vasoconstrictive response to contrast medium. The role of sodium balance and the renin-angiotension system. J. Lab. Clin. Med. 101: 385–391, 1983.

    PubMed  CAS  Google Scholar 

  15. Barshay, M.D., Kaye, J.H., Goldman, R., Coburn, J.W.: Acute renal failure in diabetic patients after infusion pyelography. Clin. Nephrol. 1: 35–39, 1973.

    PubMed  CAS  Google Scholar 

  16. Harkonen, S., Kjellstrand, C.: Contrast nephropathy. Am. J. Nephrol. 1: 69–77, 1981.

    Article  PubMed  CAS  Google Scholar 

  17. Teruel, J.L., Marcen, R., Onaindia, J.M., Serrano, A., Quereda, C., Ortuno, J.: Renal function impairment caused by intravenous urography. A prospective study. Arch. Int. Med. 141: 1271–1274, 1981.

    Article  CAS  Google Scholar 

  18. Weinrauch, L.A., Healy, R.W., Leland, U.S., Goldstein, H.H., Kassissieh, S.D., Libertino, J.A., Takacs, F.J., D’Elia, J.A.: Coronary angiography and acute renal failure in diabetic azotemic nephropathy. Ann. Intern. Med. 86: 56–59, 1977.

    PubMed  CAS  Google Scholar 

  19. Ansari, Z., Baldwin, D.S.: Acute renal failure due to radiocontrast agents. Nephron 17: 28–40, 1976.

    Article  PubMed  CAS  Google Scholar 

  20. De Fronzo, R.A., Humphrey, R.L., Wright, J.R., Cook, C.R.: Acute renal failure in multiple myeloma. Medicine 54: 209–223, 1975.

    Article  Google Scholar 

  21. Myers, G.H., Witten, D.M.: Acute renal failure after excretory urography in multiple myeloma. Am. J. Roentgenol. 113: 583–588, 1971.

    Google Scholar 

  22. Hunt, D.A., Molden, M.C., Humes, H.D.: The effect of radiocontrast agent diatrizoate, on the function of critical renal membranes. 18th Ann. Meet. Am. Soc. Nephrol., Dec. 15–18, 1985, 153A.

    Google Scholar 

  23. Talner, L.B., Rushman, H.N., Coel, M.N.: The effect of renal artery injection of contrast material on urinary enzyme excretion. Invest. Radiol. 7: 311–322, 1972.

    Article  PubMed  CAS  Google Scholar 

  24. Hartmann, H.G., Braedel, H.E., Jutzler, G.A.: Detection of renal tubular lesions after abdominal aortography and selective renal arteriography by quantitative measurements of brush-border enzymes in the urine. Nephron 39: 95–101, 1985.

    Article  PubMed  CAS  Google Scholar 

  25. Norby, L.H., DiBona, G.F.: The renal vascular effects of meglumine diatrizoate. J. Pharmacol. Exp. Ther. 193: 932–940, 1975.

    PubMed  CAS  Google Scholar 

  26. Humes, H.D., Hunt, D.A., Tekkanat, K., Holden, M.C.: Toxic effects of n-methylglucosamine on rabbit proximal tubule segments. Am. Soc. Clin. Invest., 1985.

    Google Scholar 

  27. Moreau, J.F., Droz, D., Noel, L.H., et al: Tubular nephrotoxicity of water-soluble iodinated contrast media. Invest. Radiol. 15 (Suppl) S54 - S60, 1980.

    Article  PubMed  CAS  Google Scholar 

  28. Katzberg, R.W., Schulman, G., Meggs, L.G., Caldicott, W.J.H., Damiand, M.M., Hollenberg, N.K.: Mechanism of the renal response to contrast medium in dogs: Decrease in renal function due to hypertonicity. Invest. Radiol. 18: 74–80, 1983.

    Article  PubMed  CAS  Google Scholar 

  29. Golman, K., Almen, T.: Contrast media-induced nephrotoxicity. Survey and present state. Invest. Radiol. 20: S92 - S97, 1985.

    Article  PubMed  CAS  Google Scholar 

  30. Holtas, S., Golman, K., Tornquist, C.: Proteinuria following nephroangiography VIII. Comparison between diatrizoate and tohexol in rats. Acta. Radiol. (Suppl) 362: 53–56, 1980.

    CAS  Google Scholar 

  31. White, M.D., Hunt, D.A., Humes, H.D.: Ability of the radiocontrast agent, diatrizoate, to precipitate renal tubules and membranes. 18th Ann. Metting of American Soc. Nephrol. Dec. 15–18, 1985, 163A.

    Google Scholar 

  32. Schwartz, R.H., Berdon, W.E., Wagner, H.E., Becker, J., Baker, O.H.: Tatum-hors fall urinary mucoprotein precipitation by urographic contrast agents. Am. J. Roentgenol 108: 698–701, 1970.

    CAS  Google Scholar 

  33. Katzberg, R.W., Morris, T.W., Burgener, F.A.: Renal renin and hemodynamic responses to selective renal artery catheterization and angiography. Invest. Radiol. 12: 381–388, 1977.

    Article  PubMed  CAS  Google Scholar 

  34. Russell, S.B., Sherwood, T.: Monomer/dimer contrast media in the renal circulation: Experimental angiography. Br. J. Radiol. 47: 268271, 1974.

    Google Scholar 

  35. Morris, T.W., Katzberg, R.W., Fischer, H.W.: A comparison of the hemodynamic response to metrizamide and meglunine/sodium diatrizoate in canine renal angiography. Invest. Radiol. 13: 74–78, 1978.

    Article  PubMed  CAS  Google Scholar 

  36. Bakris, G.L., Burnett, J.C., Jr.: A role for calcium in radiocontrastinduced reductions in renal hemodynamics Kidney Int. 27: 465–468, 1985.

    CAS  Google Scholar 

  37. Dean, R.W., Andrew, J.H., Read, R.C.: The red cell factor in renal damage from angiographic media. J. Am. Med. Ass. 187: 27–31, 1964.

    Article  CAS  Google Scholar 

  38. Katzberg, R.W., Pabico, R.C., Morris, T.W., Hayakawa, K., McKenna, B.A., Panner, B.J., Ventura, J.A., Fisher, H.W.: Effects of contrast media on renal function and subcellular morphology in the dog. Invest. Radiol. 21: 64–70, 1986.

    Article  PubMed  CAS  Google Scholar 

  39. Kleinknecht, D., Deloux, J., Hornberg, J.L.: Acute renal failure after intravenous urography: Detection of antibodies against contrast media. Clin. Nephrol. 2: 116–119, 1974.

    PubMed  CAS  Google Scholar 

  40. Lasser, E.C.: Etiology of Anaphylactoid Responses: The promise of nonionics. Invest. Radiol. 20 (Suppl): 79–82, 1985.

    Article  Google Scholar 

  41. Light, J.A., Perloff, L.J., Etheredge, E.E., Hill, G., Spees, E.K.: Adverse effects of meglumine diatrizoate on renal function in the early post-transplant period. Transplantation 20: 404–409, 1975.

    Article  PubMed  CAS  Google Scholar 

  42. Heidemann, M., Claes, G., Nilson, A.E.: The risk of renal allograft rejection following angiography. Transplantation 21: 289–293, 1976.

    Article  Google Scholar 

  43. Lang, J.H., Lasser, E.C., Kolb, W.P.: Activation of serum complement by contrast media. Invest. Radiol. 11: 303–308, 1976.

    Article  PubMed  CAS  Google Scholar 

  44. Kamdar, A., Weidmann, P., Makoff, D.L., Massry, S.G.: Acute renal failure following intravenous use of radiographic contrast dyes in patients with diabetes mellitus. Diabetes 26: 643–649, 1977.

    Article  PubMed  CAS  Google Scholar 

  45. Fang, L.S.T., Sirota, R.A., Ebert, T.H., Lichtenstein, N.S.: Low fractional excretion of sodium with contrast media induced acute renal failure. Arch. Intern. Med. 140: 531–533, 1980.

    Article  PubMed  CAS  Google Scholar 

  46. Ramirez, G., O’Neill, W.M., Lambert, R., Bloomer, A.: Cholesterol Embolization, a complication of angiography. Arch. Intern. Med. 138: 1430–1432, 1978.

    Article  PubMed  CAS  Google Scholar 

  47. Smith, M.C., Ghose, M.K., Henry, A.R.: The clinical spectrum of renal cholesterol embolization. Am. J. Med. 71: 174–180, 1981.

    Article  PubMed  CAS  Google Scholar 

  48. Almen, T.: Development of nonionic contrast media. Invest. Radiology 20 (Suppl): 2–9, 1985.

    Article  CAS  Google Scholar 

  49. Speck, V., Mutzel, W., Mannesmann, G., Pfeiffer, H., Siefert, H.M.: Pharmacology of noinoic dimers. Invest. Radiol. 15 (Suppl):317–322, 19 80.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, University of Southern California, Los Angeles, California, 90033, USA

    Vito M. Campese & Kunitoshe Iseki

Authors
  1. Vito M. Campese
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kunitoshe Iseki
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Bari, Bari, Italy

    Alberto Amerio  & Pasquale Coratelli  & 

  2. University of Southern California, Los Angeles, California, USA

    Vito M. Campese  & Shaul G. Massry  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Campese, V.M., Iseki, K. (1987). Contrast-Induced Acute Renal Failure. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Acute Renal Failure. Advances in Experimental Medicine and Biology, vol 212. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8240-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8240-9_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8242-3

  • Online ISBN: 978-1-4684-8240-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation