Nephrogenic Diabetes Insipidus and Distal Tubular Acidosis in Methicillin-Induced Interstitial Nephritis
- 96 Downloads
Acute interstitial nephritis associated with methicillin therapy has been reported in over 100 patients (1) and new cases are usually no more reported. Although its clinical picture has been extensively described (2–5), little attention has been paid to the possible occurrence of functional impairment of the distal tubule. This report deals with two patients with methicillin-induced interstitial nephritis and renal failure in whom distal tubular abnormalities were prominent.
KeywordsInterstitial Nephritis Nephrogenic Diabetes Insipidus Acute Interstitial Nephritis Distal Renal Tubular Acidosis Mild Renal Insufficiency
Unable to display preview. Download preview PDF.
- 5.D. Kleinknecht, A. Kanfer, L. Morel-Maroger and J.Ph. Méry, Immunologically mediated drug-induced acute renal failure, Contr. Nephrol. 10: 42 (1978).Google Scholar
- 15.N.S. Bricker and L. Fine, The renal response to progressive nephron loss, in “The Kidney”, B.M. Brenner and F.C. Rector, ed., Saunders, Philadelphia (1981).Google Scholar
- 21.M.L. Halperin, M.B. Goldstein, A. Haid, M.D. Johnson and B.J. Stinebaugh, Studies on the pathogenesis of type 1 (distal) renal tubular acidosis as revealed by the urinary pCO2 tensions, J. Clin. Invest. 49: 596 (1974).Google Scholar