A Clinical Insight into the Pathophysiology of Drug-Induced Acute Renal Failure

  • Luigi Minetti
  • Raffaele Galato
  • Loredana Radaelli
  • Carlo Rovati
  • Massimo Seveso
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 212)


A major subset of drug-induced acute renal failure (DI-ARF) is the drug-induced acute tubular necrosis (DI-ATN). Drug-induced acute interstitial nephritis, acute glomerulonephritis, and acute renal vasculitis are other subsets of DI-ARF, that unlike DI-ATN are immunologically mediated. They present morphologic and functional changes quite similar to those of corresponding idiopathic forms. Likewise, the drug-induced acute tubular necrosis (DI-ATN) is currently believed to show clinical, histological and functional features not distinguishable from those of post-ischemic ATN (IS-ATN). Whereas it appears that prolonged renal ischemia is the most common pathogenetic factor of the latter, direct nephrotoxin exposure is the etiologic factor commonly encountered in patients developing DI-ATN.


Proximal Tubule Distal Tubule Urinary Sodium Acute Interstitial Nephritis Acute Glomerulonephritis 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Luigi Minetti
    • 1
  • Raffaele Galato
    • 1
  • Loredana Radaelli
    • 1
  • Carlo Rovati
    • 1
  • Massimo Seveso
    • 1
  1. 1.Division of NephrologyCa’Granda HospitalMilanoItaly

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