A Clinical Insight into the Pathophysiology of Drug-Induced Acute Renal Failure
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A major subset of drug-induced acute renal failure (DI-ARF) is the drug-induced acute tubular necrosis (DI-ATN). Drug-induced acute interstitial nephritis, acute glomerulonephritis, and acute renal vasculitis are other subsets of DI-ARF, that unlike DI-ATN are immunologically mediated. They present morphologic and functional changes quite similar to those of corresponding idiopathic forms. Likewise, the drug-induced acute tubular necrosis (DI-ATN) is currently believed to show clinical, histological and functional features not distinguishable from those of post-ischemic ATN (IS-ATN). Whereas it appears that prolonged renal ischemia is the most common pathogenetic factor of the latter, direct nephrotoxin exposure is the etiologic factor commonly encountered in patients developing DI-ATN.
KeywordsProximal Tubule Distal Tubule Urinary Sodium Acute Interstitial Nephritis Acute Glomerulonephritis
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