Influence of Some Uremic Toxins on Oxygen Consumption of Rats in Vivo and in Vitro
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Hypothermia is secondary to a severe reduction of the metabolic rate because nephrectomized rats, maintained at a normal body temperature by housing them in a thermostat, did not improve oxygen consumption.l0
Hypothermia and hypometabolism occur at a normal pO2 of arterial blood, a rather elevated blood pressure10 and a normal cardiac output (unpublished results).
Correction of extracellular pH in uremia by bicarbonate treatment does not ameliorate the metabolic situation.10
Pretreatment with triiodothyronine (T3) over a period of 3 days does not prevent the reduction of oxygen consumption following nephrectomy.6 As such a pretreatment prevents the reduction of the metabolic rate in cyanide, fluoride and digitoxin intoxication, the lacking effect of T3 in uremia may be considered to some degree as a specific phenomenon.4
KeywordsOxygen Consumption Liver Slice Uremic Patient Uremic Toxin Oxygen Saturation Tissue
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