Effects of Endotoxin on Hemodynamics of Isolated Dog Kidney
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Endotoxin have been incriminated in the pathogenesis of acute renal failure in liver disease1,2. The altered renal function has been attributed to intense renal vasoconstriction and to a fall in renal perfusion pressure. Many authors3,4,5,6,7,8,9 postulated that the vasoconstriction was due to both a direct local action of endotoxin on the renal vascular bed and to secondary systemic release of vasocontrictor agents during the systemic hypotension. In an attempt to separate the systemic hemodynamic effects of endotoxin from a direct action of these substances on the kidney, we studied the influence of exogenous endotoxin on isolated dog kidney perfusions.
KeywordsRenal Blood Flow Fulminant Hepatic Failure Renin Angiotensin System Renal Perfusion Pressure Control Kidney
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- 1.H. LIEHR AND A. JACOBS, Endotoxin and renal failure in liver disease, in: “The kidney in liver disease”, M. Epstein, ed., Elsevier Biomedical, New York, Amsterdam, Oxford (1983).Google Scholar
- 2.P. CORATELLI, G. PASSAVANTI, I. MUNNO, D. FUMAROLA and A. AMERIO, New Trends in Hepatorenal Syndrome, Kidney Int. 28 (suppl 17):s-143 (1985)Google Scholar
- 6.S. WILKINSON, V. ARROYO, B. GAZZARD, H. MOODIE, R. WILLIAMS, Relation of renal impairment and haemorrhagic diathesis to endotoxemia in fulminant hepatic failure, Lancet: 521 (1974).Google Scholar
- 7.S. WILKINSON, B. PORTMANN, D. HURST and R. WILLIAMS, Pathogenesis of renal failure in cirrhosis and fulminant hepatic failure, Postgrad. Med. J. 54: 503 (1975).Google Scholar
- 11.R. TREE, Measurement of plasma renin substrate in man, J. Endocr. 56: 159A (1973).Google Scholar