Abstract
The antibiotic actinomycin D, together with similar actinomycin compounds, was isolated from cultures of Streptomyces and described according to chemical structure [1–6]. A highly labeled actinomycin D was recently synthesized [7]. The toxicity of the actinomycins in animals has been studied [8, 9], and their therapeutic usefulness and toxic manifestations in humans are known [10, 11].
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Manaker, R.A., Gregory, F. J., Vining, L.C., and Waksman, S.A.: Actinomycin: III. The properties of a new actinomycin, Antiobiotics Annual, Medical Encyclopedia, Inc., New York, 1954–1955, pp. 853–857.
Bullock, E., and Johnson, A. W.: Actinomycin: Part V. The structure of actinomycin D, Article 624, J. Chem. Soc.: 3280–3285, 1957.
Waksman, S.A., and Woodruff, H. B.: Bacteriostatic and bacteriocidal substances produced by a soil Actinomyces. Proc. Soc. Exptl. Biol. Med. 45: 609, 1940.
Brockmann, H., Bohnsack, H., Franck, B., Gróne, H., Muxfeldt, H., and Riling, C. H.: Neue farbige Produkte der Actinomycine, Angew. Chem. 68: 70, 1956.
Katz, E., and Weissbach, H.: Incorporation of C14 -labeled amino acids into actinomycin and protein by Streptomyces antibioticus, J. Biol. Chem. 238 (2): 66–675, 1963.
Katz, E.: Biogenesis of the actinomycins, Ann. N.Y. Acad. Sci. 89: 304–322, 1962.
Katz, E., Mauger, A.B., and Weissbach, H.: Biosynthesis of highly labeled actinomycins. Mol. Pharmacol. 1 (1): 107–109, 1965.
Waksman, S.A., Robinson, H., Metzger, H. J., and Woodruff, H.B.: Toxicity of actinomycin, Proc. Soc. Exptl. Biol. Med. 47: 261–263, 1941.
Philips, F. S., Schwartz, H.S., Sternberg, S. S., and Tan, C. T. C.: The toxicity of actinomycin D, Ann. N.Y. Acad. Sci. Part II, Pharmacological and Experimental 89: 348–360, 1960.
Moore, G.E., Di Paolo, J.A., and Kondo,T.: The chemotherapeutic effects and complications of actinomycin D in patients with advanced cancer, Cancer 11: 1204–1214, 1958.
Shaw, R. K., Moore, E. W., Muller, P. S., Frei, Emil, III, and Watkin, D. W.: The effect of actinomycin D on childhood neoplasms, Am. J. Diseases Children 99: 628–635, 1960.
Reich, E., Franklin, R. M., Shatkin, A. J., and Tatum, E.L.: Effect of actinomycin D on cellular nucleic acid synthesis and virus production, Science 134: 556–557, 1961.
Ficq, A.: Effets de l’actinomycine D et de la puromycine sur le métabolisme de l’oocyte en croissance. Etude autoradiographique, Exptl. Cell Res. 34: 581–594, 1964.
Cavalieri, L. F., and Nemchin, R.G.: Biochim. Biophys. Acta 87: 641, 1964.
Goldberg, I. H., Rabinowitz, M., and Reich, E.: Proc. Natl. Acad. Sci. U.S. 48: 2094, 1962.
Kersten, W., Kersten, H., and Szybalski, W.: Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chromomycin, mithramycin, and olivomycin), Biochemistry 5 (1): 236–244, 1966.
Hebb, D.O.: The Organization of Behavior, John Wiley and Sons, New York, 1949.
Weiss, P.A.: in: Analysis of Development, W.B. Saunders Company, Philadelphia, 1955, p. 365.
Hydén, H.: in Brachet, J., and Minsky, A. (editors): The Cell, Biochemistry, Physiology, Morphology, Vol. 4, Academic Press, New York, 1960, Chap. 5.
Cameron, D.E., and Solyom, L.: Effects of ribonucleic acid on memory, Geriatrics 16: 74–81, 1961.
Plotnikoff, N.: Magnesium pemoline: Enhancement of learning and memory of a conditioned avoidance response, Science 151 (3711): 703–704, 1966.
Glasky, Alvin J.: Magnesium pemoline: Enhancement of brain RNA polymerases, Science 151 (3711): 702–703, 1966.
Dingman, W., and Sporn, M. B.: The incorporation of 8-azaguanine into rat brain RNA and its effect on maze-learning by the rat: An inquiry into the biochemical basis of memory, J. Psychiat. Res. 1: 1, 1961.
Flexner, J.B., Flexner, L.B., and Stellar, E.: Memory in mice as affected by íntracerebral puromycin, Science 141:57.-59, 1963.
Agranoff, B.W., Davis, R.E., and Brink, J. J.: Proc. Natl. Acad. Sci. U.S. 54: 788, 1965.
Barondes, S. H.,, and Jarvik, M.E.: The influence of actinomycin D on brain RNA synthesis and on memory, J. Neurochem. 11: 187–195, 1964.
Appel, S. H.: Effect of inhibition of RNA synthesis on neural information storage, Nature 207 (5002): 1163–1166, 1964.
Barondes, S. H.: Relationship of biological regulatory mechanisms to learning and memory, Nature 205: 18–21, 1965.
Barondes, S. H., and Cohen, Harry D.: Puromycin effect on successive phases of memory storage, Science 151 (3710): 594–595, 1966.
Cohen, H. D., and Barondes, S. H.: Further studies of learning and memory after intra-cerebral actinomycin D, J. Neurochem. 13: 207–211, 1966.
Flexner, L.B., and Flexner, J.B.: Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice, Proc. Natl. Acad. Sci. U.S. 55: 369–374, 1966.
Barron, K. D., and Tuncbay, T. O.: Phosphatase in cuneate nuclei after brachial plexectomy, Arch. Neurol. 7: 203–210, 1962.
Reynolds, R.C., Montgomery, P. O’B., and Hughes, B.: Nucleolar “caps” produced by actinomycin D, Cancer Res. 24 (7): 1269–1277, 1964.
Levy, H. B.: Effect of actinomycin D on HeLa cell nuclear RNA metabolism, Proc. Soc. Exptl. Biol. Med. 113: 886–889, 1963.
Koenig, H.: Experimental myelopathy produced with pyrimidine analogue, A.M.A. Arch. Neurol. 2: 463–475, 1960.
Kurth, L. E., Jr., Koenig, H., and Freyre, J.: Frontal lobe encephalopathy with focal seizures produced with pyrimidine analogs, Trans. Am. Neurol. Assoc.: 215–216, 1960.
Greenfield, J.G.: Neuropathology, Edward Arnold, Ltd., 1961, p. 88.
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Rowley, W.F., Young, I.J. (1967). Experimental Myelopathy and Encephalopathy Induced by Actinomycin D. In: Wortis, J. (eds) Recent Advances in Biological Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8228-7_18
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DOI: https://doi.org/10.1007/978-1-4684-8228-7_18
Publisher Name: Springer, Boston, MA
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