Abstract
Recently we called attention to a general relationship prevailing between the taste threshold of stereospecific drugs and their biological activity [1, 2]. For example, with 1-quinine and d-quinine, as well as with d-amphetamine and 1-amphetamine, the former of each drug pair is the biologically more potent compound, as indicated by its lower oral LD50 in the mouse. Correspondingly, humans can taste the more active compound in a lower concentration (i.e., they display lower taste thresholds). For these reasons we came to regard a subject’s oral cavity as a pharmacological test preparation in situ and the taste response as a sensory expression of pharmacological activity.
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References
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Fischer, R., Kaelbling, R. (1967). Increase in Taste Acuity with Sympathetic Stimulation: The Relation of a Just-Noticeable Taste Difference to Systemic Psychotropic Drug Dose. In: Wortis, J. (eds) Recent Advances in Biological Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8228-7_13
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DOI: https://doi.org/10.1007/978-1-4684-8228-7_13
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