Experimental Model in the Cat for Cerebral Sino-Venous Occlusion

  • S. Kannuki
  • J. Cervos-Navarro
  • K. Matsumoto
  • Y. Nakagawa


Cerebral sinus vein thrombosis (CSVT) leads to a wide range of changes in brain tissue and to various clinical syndromes. This variability is due to the many different collateral connections of the venous circulation. It was formerly believed that CSVT has consistently a poor prognosis and high mortality (8). Although recent publications report CSVT cases with a favorable prognosis, severe hemorrhagic venous infarction still has a poor outcome. Further, treatment of CSVT is still controversial. In the present study, the superior sagittal sinus (SSS) of 22 cats was occluded by embolization using a polymer. Extravasation of tracers indicating changes of blood-brain barrier (BBB) permeability was studied and correlated with histological changes induced by SSS occlusion. In addition, regional cerebral blood flow (rCBF) as well as brain edema measured as increase in water content of brain tissue using a freeze-drying method were studied. Brain edema was also correlated with changes of the BBB permeability.


Regional Cerebral Blood Flow Sinus Thrombosis Superior Sagittal Sinus Subcortical White Matter Partial Occlusion 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • S. Kannuki
    • 1
  • J. Cervos-Navarro
    • 1
  • K. Matsumoto
    • 2
  • Y. Nakagawa
    • 2
  1. 1.Institute of Neuropathology, Klinikum SteglitzFree University of BerlinGermany
  2. 2.Department of Neurological SurgeryTokushima UniversityJapan

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