Experimental Model in the Cat for Cerebral Sino-Venous Occlusion
Cerebral sinus vein thrombosis (CSVT) leads to a wide range of changes in brain tissue and to various clinical syndromes. This variability is due to the many different collateral connections of the venous circulation. It was formerly believed that CSVT has consistently a poor prognosis and high mortality (8). Although recent publications report CSVT cases with a favorable prognosis, severe hemorrhagic venous infarction still has a poor outcome. Further, treatment of CSVT is still controversial. In the present study, the superior sagittal sinus (SSS) of 22 cats was occluded by embolization using a polymer. Extravasation of tracers indicating changes of blood-brain barrier (BBB) permeability was studied and correlated with histological changes induced by SSS occlusion. In addition, regional cerebral blood flow (rCBF) as well as brain edema measured as increase in water content of brain tissue using a freeze-drying method were studied. Brain edema was also correlated with changes of the BBB permeability.
KeywordsRegional Cerebral Blood Flow Sinus Thrombosis Superior Sagittal Sinus Subcortical White Matter Partial Occlusion
Unable to display preview. Download preview PDF.
- 1.J. H. Adams, J. A. N. Corsellis and L. W. Duchen, eds, “Greenfield’s Neuropathology”, 4th ed, Wiley-Medical Publication, New York (1984).Google Scholar
- 2.D. J. K. Beck and D. S. Russell, Experiments on thrombosis of the superior longitudinal sinus, Neurosurgery 3: 693 (1946).Google Scholar
- 4.K. Frerichs, M. Deckert, M. Jansen, O. Kempski, K. Einhäupl and A. Baethmann, Brain function and morphology in experimental sinus-vein thrombosis, J. Cereb. Blood Flow & MetabL, 7 (Suppl. 1): 57 (1987).Google Scholar
- 5.K. Fujita, N. Kojima and S. Matsumoto, Brain edema in experimental intracranial hypertension, in: “Brain Edema”, Y. Inaba, I. Klatzo and M. Spatz, eds., Springer Verlag, Berlin, Heidelberg and New York (1986).Google Scholar
- 7.P. G. Gates and H. J. M. Barnett, Venous disease: cortical veins and sinuses, in: “Stroke”, vol. 2, H. J. M. Barnett, B. M. Stein, J. P. Mohr and F. M. Yatsu, eds., Churchill Livingstone, New York, Edinburgh, London and Melbourne (1986).Google Scholar
- 9.M. L. Marcus, D. D. Heistad, J. C. Ehrhardt and F. M. Abboud, Total and regional cerebral blood flow measurement with 7, 10, 15, 25 and 50 gm microspheres, J. Appt Physiol., 40: 501 (1976).Google Scholar
- 10.M. Miyagami, S. Nakamura and N. Moriyasu, Hydrodynamic of the CSF under experimental occlusion of the superior sagittal sinus, Neurosurg. Tokyo, 3: 739 (1975).Google Scholar
- 11.M. Miyagami, S. Nakamura and N. Moriyasu, Ventricular enlargement in experimental occlusion of superior sagittal sinus - in reference to histopathological findings, Neurosurg. Tokyo, 3: 947 (1975).Google Scholar
- 14.S. Sato, M. Ohtani and T. Kawase, The effect of sagittal sinus occlusion on blood-brain barrier permeability and cerebral blood flow in the dog, in: “Brain Edema”, Y. Inaba, I. Klatzo and M. Spatz, eds., Springer Verlag, Berlin, Heidelberg, New York and Tokyo (1986).Google Scholar