Membrane Resistance to Oxygen Transport Inside Hybridoma Cells in Suspension Culture
Monoclonal antibodies (MAb) have been used as valuable analytical, diagnostic, and therapeutic tools for modern bioscience and medicine. Because of their high specificity, monoclonal antibodies have also been used for the purification of biomaterials which need high purity. Due to the high demand for monoclonal antibodies hybridoma cell culture, which enables one to produce monoclonal antibodies in large quantity, has become one of the most interesting topics and has been studied by many biochemical engineers.
KeywordsDissolve Oxygen Concentration Oxygen Transport Oxygen Consumption Rate Mass Transfer Resistance Oxygen Diffusion Coefficient
Unable to display preview. Download preview PDF.
- Balentine, J. D., Pathology of Oxygen Toxicity, Academic Press, New York, 1982.Google Scholar
- Chillakuru, R., 1989, Personal Communication.Google Scholar
- Mizrahi, A., Vosseller, G. V., Yagi, Y., and Moore, G. E., 1972, “The Effect of Dissolved Oxygen Partial Pressure on Growth, Metabolism and Immunoglobulin Production in a Permanent Human Lymphocyte Cell Line Culture”, 139, P.S.E.B.M., 118–122.Google Scholar
- Oberley, L. W., Superoxide Dismutase and Cancer, 1982, in: “Superoxide Dismutase”, Vol II, edited by Oberley, L. W., CRC Press, Boca Raton, Florida.Google Scholar
- Frank, L., Oxygen Toxicity in Eukaryotes, 1985, in: “Superoxide Dismutase”, Vol III, edited by Oberley, L.W., CRC Press, Boca Raton, Florida.Google Scholar
- Satterfield, C. N., 1970, “Mass Transfer in Heterogeneous Catalysis”, MIT press, Massachusetts.Google Scholar