Abstract
Placental insufficiency leading to fetal growth retardation is a significant obstetrical problem. Fetal hypoxia resulting from placental insufficiency may have detrimental effects on the fetus as a whole and, depending on the time during organogenesis when the hypoxic insult occurs, may alter normal development of specific organ systems. Hypoxia has been shown to effect normal cardiac growth in neonatal rats (Hollenberg et al., 1976). Within the heart, changes in the growth and maturation of cardiac myocytes and the coronary vasculature may result.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Biro, G. P. and Biais, P., 1987, Perfluorocarbon blood substitutes. CRC Crit. Rev. Oncol./Hematol., 6:311.
Cefalo, R. C., Seeds, J. W., Proctor, H. J. and Baker, V. V., 1984, Maternal and fetal effects of exchange transfusion with a red blood cell substitute. Am. J. Obstet. Gynecol., 148:859.
Dbaly, J., Ostadal, B. and Rychter, Z., 1968, Development of the coronary arteries in rat embryos. Acta Anat., 71:209.
Doenicke, A., Grote, B. and Lorenz, W., 1977, Blood and blood substitutes. Br. J. Anaesthesiol., 49:681.
Faithfull, N. S. and Marshall, H. W., 1989, The effect of fluorocarbon emulsion on placental insufficiency. In: Oxygen Transport to Tissue-XI, K. Rakusan, G. Biro, T. K. Goldstick and Z. Turek, eds., Plenum Press, New York, p. 357.
Faithfull, N. S., Fennema, M., Erdmann, W., Lapin, R., Smith, A. R., van Alphen, W., Essed, C. E. and Trouwborst, A., 1985, Tissue oxygenation by fluorocarbons. Adv. Exp. Med. Biol., 180:569.
Hollenberg, M., Honbo, N. and Samorodin, A. J., 1976, Effects of hypoxia on cardiac growth in neonatal rat. Am. J. Physiol., 231:1445.
Ostadal, B., Schiebler, T. H. and Rychter, Z., 1975, Relations between development of the capillary wall and myoarchitecture of the rat heart. Adv. Exp. Med. Biol., 53:375.
Rychter, Z., Jelinek, R. and Marhan, O., 1971, Progress of vascularization of the ventricular myocardium in the rat embryo. Physiol. Bohemoslov., 20:527.
Rychter, Z., Jelinek, R. and Marhan, O., 1972, Shape and location of non-vascularized area of ventricular myocardium in rat embryo during terminal phase of heart vascularization. Folia Morphol., 20:21.
Vercellotti, G. M. and Hammerschmidt, D. E., 1985, Immunological biocompatibility in blood substitutes. Int. Anesth. Clin., 23:47.
Vercellotti, G. M., Hammerschmidt, D. E., Craddock, P. R. and Jacob, H. S., 1982, Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroid prophylaxis. Blood, 59:1299.
Vileisis, R. A., 1985, Effect of maternal oxygen inhalation on the fetus with growth retardation. Ped. Res., 19:324.
Wigglesworth, J. S., 1964, Experimental growth retardation in the foetal rat. Pathol. Bacteriol., 88:1.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Campbell, S.E., Rakusan, K., Faithfull, N.S. (1990). Coronary Capillary Development Following Treated and Untreated Fetal Hypoxia in the Rat. In: Piiper, J., Goldstick, T.K., Meyer, M. (eds) Oxygen Transport to Tissue XII. Advances in Experimental Medicine and Biology, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8181-5_30
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8181-5_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8183-9
Online ISBN: 978-1-4684-8181-5
eBook Packages: Springer Book Archive