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DNA Damage of the 5,6-Dihydroxydihydrothymine Type Induced by Solar UV-B in Human Cells

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The Role of Solar Ultraviolet Radiation in Marine Ecosystems

Part of the book series: NATO Conference Series ((MARS,volume 7))

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Abstract

The magnitude of an acute skin dose of ionizing radiation which produces an abundance of 5,6-dihydroxydihydrothymine (t′) equal to that produced by a plausible daily exposure to solar UV (313±6 nm) is calculated to range from 0.27 krad (winter) to 5.65 krad (summer) in temperate latitudes. Considering the evidence for the possible biological importance of the t′ lesion, and the carcinogenicity of a 1.6 krad acute skin dose of ionizing radiation in one strain of rat, these t′ damage. equivalent doses emphasize the magnitude of the challenge presented by solar UV-B.

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Authors and Affiliations

  1. Department of Biophysics, Roswell Park Memorial Institute, Buffalo, New York, 14263, USA

    P. V. Hariharan & E. R. Blazek

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  1. P. V. Hariharan
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  2. E. R. Blazek
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Editor information

Editors and Affiliations

  1. Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky, USA

    John Calkins

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© 1982 Plenum Press, New York

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Hariharan, P.V., Blazek, E.R. (1982). DNA Damage of the 5,6-Dihydroxydihydrothymine Type Induced by Solar UV-B in Human Cells. In: Calkins, J. (eds) The Role of Solar Ultraviolet Radiation in Marine Ecosystems. NATO Conference Series, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8133-4_30

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  • DOI: https://doi.org/10.1007/978-1-4684-8133-4_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8135-8

  • Online ISBN: 978-1-4684-8133-4

  • eBook Packages: Springer Book Archive

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