Abstract
Immunological adjuvants, as well as a variety of chronic infections, stimulate the reticuloendothelial system and induce a population of activated macrophages exhibiting potent bacteriostatic and tumoricidal capacities.1,2 Cytotoxic macrophages can also be induced in vitro by the activation of macrophages with non-specific stimuli, such as endotoxin, Poly I•Poly C, or with soluble mediators released by stimulated lymphocytes.3–5 Ruco and Meltzer found that peritoneal macrophages,induced in vivo by acute inflammatory agents, are at least 10 times more responsive to activation by lymphokines than normal-resident peritoneal macrophages.6 The macrophages, that are mobilized to inflammatory and tumor growth sites, are mature monocytes in transit in peripheral blood from their site of generation — the bone marrow. Lohmann-Matthes et al.7 showed that macrophages, differentiating in vitro from bone marrow cell precursors, can be activated by lymphokines for tumor cell cytotoxicity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. B. Hibbs, H. A. Chapman and J. B. Weinberg, The macrophage as an antineoplastic surveillance cell: Biological perspectives, J.Ret.Soc. 24: 549 (1978).
G. B. Mackaness and R. V. Blanden, Cellular immunity, Progr. Allergy 11: 89 (1967).
P. Alexander and R. Evans, Endotoxin and double-stranded RNA render macrophages cytotoxic, Nature New Biol. 232: 76 (1971).
I. J. Fidler, Activation in vitro of mouse macrophages by syngeneic,allogeneic or xencgeneic lymphocyte supernatants, J.Natl.Cancer Inst. 55: 1159 (1975).
L. P. Ruco and M. S. Meltzer, Macrophage activation for tumor cytotoxicity: Induction of tumoricidal macrophages by PPD and BCG-immune mice, Cell.Immunol. 32: 203 (1977).
L. P. Ruco and M. S. Meltzer, Macrophage activation for tumor cytotoxicity: Increased lymphokine responsiveness of peritoneal macrophages during acute inflammation, J.Immunol. 120: 1054 (1978).
M.-L. Lohmann-Matthes, B. Kolb and H.-G. Meerpohl, Susceptibility of malignant and normal target cells to the cytotoxic action of bone-marrow macrophages activated in vitro with the macrophage cytotoxicity factor (MCF), Cell.Immunol. 41: 231 (1978).
Z. Bar-Shavit, A. Raz and R. Goldman, Complement (C3b) and Fcreceptor mediated phagocytosis of normal and stimulated mouse peritoneal macrophages, Eur.J.Immunol. 9: 385 (1979).
R. Goldman and Z. Bar-Shavit, A dual effect of normal and stimulated macrophages and their conditioned media on target cell proliferation, J.Natl.Cancer Inst. 63: 1009 (1979).
M. L. Karnovsky, J. Lazdins, D. Drath and A. Harper, Biochemical characteristics of activated macrophages, Ann.N.Y.Acad.Sci. 256: 266 (1975).
I. Bursuker and R. Goldman, Quantitative and functional differences induced in bone marrow derived mononuclear phagocytes by inflammatory stimuli, J.Rèt.Soc. 25: 533 (1979).
E. Huberman, S. Salzberg and L. Sachs, The in vitro induction of an increase in cell multiplication and cellular life span by the water-soluble carcinogen dimethyl-nitrosamine, Proc.Natl.Acad.Sci.USA 59: 77 (1968).
R. Bomford and G. H. Christie, Mechanisms of macrophage activation by CP: II. In vivo experiments, Cell.Immunol. 17: 150 (1975).
R. T. Cullen and A. Ghaffar, Possible mechanisms underlying the induction of cytotoxic macrophages by CP: In vitro induction of cytotoxicity in normal macrophages by immune lymphocytes, J.Ret.Soc. 24: 339 (1978).
M.-L. Lohmann-Matthes, W. Domzig and J. Roder, Promonocytes have the functional characteristics of natural killer cells, J.Immunol. 123: 1883 (1979).
J. C. Roder, M.-L. Lohmann-Matthes, W. Domzig, R. Keissling and O. Haller, A functional comparison of tumor cell killing by activated macrophages and natural killer cells, Eur.J. Immunol. 9: 283 (1979).
D. Boraschi and M. S. Meltzer, Defective tumoricidal capacity of macrophages from A/J mice: II. Comparison of the macrophage cytotoxic defect of A/J mice with that of lipid Aunresponsive C3H/HeJ mice, J.Immunol. 122: 1592 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Bursuker, I., Goldman, R. (1982). A Differential Responsiveness of In Vitro Differentiating Mononuclear Phagocytes from Bone Marrows of Normal and Inflamed Mice to Lymphokines and Poly I•Poly C. In: Rossi, F., Patriarca, P. (eds) Biochemistry and Function of Phagocytes. Advances in Experimental Medicine and Biology, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8088-7_7
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8088-7_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8090-0
Online ISBN: 978-1-4684-8088-7
eBook Packages: Springer Book Archive