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Effect of Ionophores on Lymphocyte Cellular Metabolism

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Biochemistry and Function of Phagocytes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 141))

Summary

The effect of valinomycin, nigericin, gramicidin S and D, A23187 and X537A on respiration and cellular ATP content of rat spleen lymphocytes is presented. It has been found that while valinomycin and nigericin interfere with mitochondrial functions, gramicidin D does not show an appreciable effect. These results are explained in terms of different ability of ionophores to redistribute among intracellular membranes. A23187 and X537A, added with Ca2+, strongly enhanced O2 consumption and reduced cellular ATP content.

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Authors and Affiliations

  1. C.N.R. Unit for the Study of Physiology of Mitochondria Institute of General Pathology, University of Padova, Via Loredan, 16, 35100, Padova, Italy

    Paola Arslan, Alda Miolo, Cesare Montecucco & Tullio Pozzan

Authors
  1. Paola Arslan
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  2. Alda Miolo
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  3. Cesare Montecucco
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  4. Tullio Pozzan
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  5. R. E. Basford
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Editor information

Editors and Affiliations

  1. Instituto di Patologia Generale dell’ Università di Padova, Verona, Italy

    Filippo Rossi

  2. Instituto di Patologia Generale dell’ Università degli Studi di Trieste, Trieste, Italy

    Pierluigi Patriarca

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© 1982 Plenum Press, New York

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Arslan, P., Miolo, A., Montecucco, C., Pozzan, T., Basford, R.E. (1982). Effect of Ionophores on Lymphocyte Cellular Metabolism. In: Rossi, F., Patriarca, P. (eds) Biochemistry and Function of Phagocytes. Advances in Experimental Medicine and Biology, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8088-7_46

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  • DOI: https://doi.org/10.1007/978-1-4684-8088-7_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8090-0

  • Online ISBN: 978-1-4684-8088-7

  • eBook Packages: Springer Book Archive

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