Abstract
The traditional focus on macrophages as phagocytic cells has recently been enlarged to include biosynthetic and secretory processes. Among such secretory products are the neutral proteases, plasminogen activator, collagenase and elastase. The latter two are particularly important in tissue injury and repair since they can attack their native insoluble substrates at neutral pH in the extra-cellular fluid. Such enzymes are not stored in macrophages, nor do they exist as proenzymes. Thus, their secretion directly depends on continuous synthesis which is known to be inhibitable by such protein synthesis inhibitors as cycloheximide.
Supported by USPHS grant HL 19237.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Z. Werb and S. Gordon, Elastase secretion by stimulated macrophages: characterization and regulation, J. Exp. Med. 142: 361 (1975).
L.M. Wahl, S.M. Wahl, S.E. Mergenhagen, and G.R. Martin, Collagenase production by lymphokine-activated macrophages, Science 187: 261 (1975).
S.M. Wahl, L.M. Wahl, J.B. McCarthy, L. Chedid, and S.E. Mergenhagen, Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide, J. Immunol. 122: 2226 (1979).
L.M. Wahl, C.E. Olsen, A.L. Sandberg, and S.E. Mergenhagen, Prostaglandin regulation of macrophage collagenase production, Proc. Natl. Acad. Sci. 74: 4955 (1977).
J.H. Passwell, J.-M. Dayer, K. Gass, and P.J. Edelson, Regulation by Fc fragments of the secretion of collagenase, PGE2, and lysozyme by mouse peritoneal macrophages, J. Immunol. 125: 910 (1980).
J.B.L. Gee, C.A. Stevens, and L.M. Hinman, Therapeutic modulation of elastase secretion by macrophages, Fed. Proc. 39 (part 1): 320 (1980).
J.B. McCarthy, S.M. Wahl, J.C. Rees, C.E. Olsen, A.L. Sandberg, and L.M. Wahl, Mediation of macrophage collagenase production by 3’-5’cyclic adenosine monophosphate, J. Immunol. 124: 2405 (1980).
W.C. Buss, R. Morgan, J. Guttmann, T. Barela, and K. Stalter, Rifampin inhibition of protein synthesis in mammalian cells, Science 200: 432 (1978).
J.B.L. Gee, C.A. Stevens, and L.M. Hinman, Inhibition by rifampin of elastase and lysozyme secretion in mouse peritoneal macrophages, Biochem. Pharmacol. 29: 3037 (1980).
J.B.L. Gee, C.A. Stevens, and L.M. Hinman, Elastase and lysozyme secretion by peritoneal macrophages: effects of dexamethasone and rifampin, J. Physiol. Path. Respiratoire. (in press).
G. Binda, E. Domenishini, A. Gottardi, B. Orlandi, E. Ortelli, B. Pacini, and G. Fowst, Rifampicin: a general review, Arzneim. Forsch (Drug Res.) 21: 1907 (1971).
R. White, J. White, and A. Janoff, Effects of cigarette smoke on elastase secretion by murine macrophages, J. Lab. Clin. Med. 94: 489 (1979).
L.M. Hinman, C.A. Stevens, R.A. Matthay, and J.B.L. Gee, Elastase and lysozyme activities in human alveolar macrophages, Am. Rev. Respir. Dis. 121: 263 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Gee, J.B.L., Stevens, C.A., Hinman, L.M., Harkness, R.A. (1982). Elastase Secretion by Mouse Peritoneal Macrophages: Effects of Rifampin and Corticosteroids. In: Rossi, F., Patriarca, P. (eds) Biochemistry and Function of Phagocytes. Advances in Experimental Medicine and Biology, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8088-7_23
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8088-7_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8090-0
Online ISBN: 978-1-4684-8088-7
eBook Packages: Springer Book Archive