Abstract
The polymorphonuclear leukocyte (PMN)† is a highly specialized cell geared to the destruction of ingested microorganisms through the concentration of toxic agents within phagocytic vacuoles. Among the microbicidal systems of the PMN is one comprised of the granule enzyme, myeloperoxidase (MPO), the product of oxygen metabolism hydrogen peroxide, and a halide cofactor such as chloride (1,2). During phagocytosis or on exposure to certain soluble activating agents, the components of the MPO system are secreted into the extracellular fluid where they exert such biologic functions as the lysis of mammalian cells (3–5), the killing of hyphal forms of invasive fungal pathogens (6), and the oxidative inactivation of humoral mediators of inflammation (7,8). I will review some of our work on the inactivation of chemotactic factors and protease inhibitors by the isolated MPO system by stimulated human PMN.
Supported by Grant CA24353 and Research Career Development Award CA00441 from the National Cancer Institute.
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Abbreviations
- DABCO:
-
diazobicyclo(2,2,2)octane
- MPO:
-
myeloperoxidase
- αl-PI:
-
αl-protease inhibitor
- PMA:
-
phorbol myristate acetate
- PMN:
-
polymorphonuclear leukocyte
- SOD:
-
superoxide dismutase
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© 1982 Plenum Press, New York
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Clark, R.A. (1982). Modulation of the Inflammatory Response by the Neutrophil Myeloperoxidase System. In: Rossi, F., Patriarca, P. (eds) Biochemistry and Function of Phagocytes. Advances in Experimental Medicine and Biology, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8088-7_22
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DOI: https://doi.org/10.1007/978-1-4684-8088-7_22
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