Abstract
The enzyme myeloperoxidase (MPO), present in high concentrations in neutrophilic granulocytes of many species, has been shown to have a bactericidal effect when combined with hydrogen peroxidase and chloride as cofactors (for a review see1). At present, the exact basis of the myeloperoxidase-mediated killing of bacteria has not yet been elucidated. Both hypochlorous acid (OCl−) and singlet oxygen (1O2) have been designated as the microbicidal agents in this system.
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© 1982 Plenum Press, New York
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Hamers, M.N., Sips, H.J., Elsbach, P. (1982). Molecular Mechanism of the Bactericidal Action of Myeloperoxidase-H2O2-Chloride. In: Rossi, F., Patriarca, P. (eds) Biochemistry and Function of Phagocytes. Advances in Experimental Medicine and Biology, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8088-7_15
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DOI: https://doi.org/10.1007/978-1-4684-8088-7_15
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