Abstract
Inhibitors of enzymic and metabolic processes are invaluable tools in biochemical and physiological research, and their application as drugs or pesticides ranges from medicine to agriculture. The information one can extract from their judicious use depends, on the one hand, on the complexity of the system to which they are applied and, on the other hand, on their selectivity for a given target, as well as on their access to this target. Accessibility in this context is meant to include the arrival of the inhibitor at its target site in a state in which it is capable of exerting its inhibitory action. It is obvious that the chances for selectivity of a given inhibitor decrease with the increasing complexity of a system as measured, for example, by the number of enzymic reactions involved and the degree of their interaction and interdependence in the metabolic network of a cell. To illustrate this point, α-aminooxy acetic acid (AOA) is a fairly potent inhibitor of the biosynthesis of phenylpropanoid compounds and has been used in complementation experiments to study the biosynthesis of cyanidin in buckwheat.1
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Amrhein, N. (1986). Specific Inhibitors as Probes into the Biosynthesis And Metabolism of Aromatic Amino Acids. In: Conn, E.E. (eds) The Shikimic Acid Pathway. Recent Advances in Phytochemistry, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8056-6_4
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