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Model: Mechanistic vs Empirical

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New Trends in Pharmacokinetics

Part of the book series: NATO ASI Series ((NSSA,volume 221))

Abstract

According to the Oxford English Dictionary, the word Model (French modèle, Italian modello, Latin modulus) has many meanings. In our context, the word could mean, ‘something that accurately resembles something else’, ‘an object of imitation’, or ‘a perfect exemplar of some excellence’. The Sanskrit equivalent of Model is ‘Pratirupa’, i.e. a perfect copy or imitation. From sociology to science, models have been used for centuries. National heroes like George Washington, Mahatma Gandhi and many others are models that many parents wish their children to follow (obviously there are hundreds of counter examples as well!). In science, the ancient Hindu mathematicians used picture models to calculate astronomical parameters. And of course, we have the model of gravity in Isaac Newton’s Apple! There is no branch of science today that does not employ models to understand the system under study. Unfortunately, even with such a long tradition, the word model still brings out a lot of confusion and disagreement. This is particularly true when the statisticians are asked to make certain statements regarding observations made in various fields. The purpose of this discussion is not to settle any controversies, but to open the door for understanding such a broad concept.

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© 1991 Plenum Press, New York

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Thakur, A.K. (1991). Model: Mechanistic vs Empirical. In: Rescigno, A., Thakur, A.K. (eds) New Trends in Pharmacokinetics. NATO ASI Series, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8053-5_3

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  • DOI: https://doi.org/10.1007/978-1-4684-8053-5_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8055-9

  • Online ISBN: 978-1-4684-8053-5

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