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Schwann Cell Proliferation during Postnatal Development, Wallerian Degeneration and Axon Regeneration in Trembler Dysmyelinating Mutant

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Plasticity and Regeneration of the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 296))

Abstract

During mouse ontogenesis, Schwann cells in peripheral nerves migrate along the axons and begin the process of ensheathment (1,2). Subsequently, Schwann cells divide intensely, from the end of gestation (1) till the first days of postnatal development (3,4). The high rate of Schwann cell proliferation decreases rapidly and stops totally during the process of myelination (1,3).

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References

  1. A. Peters and A.R. Muir, The relationship between axons and Schwann cells during development of peripheral nerves in the rat, Q.J. Exp. Physiol., 64:117 (1959).

    Google Scholar 

  2. C.C. Speidel, In vivo studies of myelinated nerve fibers, Int. Rev. Cytol., 16:173 (1964).

    Article  PubMed  CAS  Google Scholar 

  3. A.K. Asbury, Schwann cell proliferation in developing mouse sciatic nerve, J. Cell Biol., 34:736 (1967).

    Article  Google Scholar 

  4. L.C. Terry, G.M. Bray and A.J. Aguayo, Schwann cell multiplication in developing rat unmyelinated nerves. A radioautographic study, Brain Res., 69:144 (1974).

    Article  PubMed  CAS  Google Scholar 

  5. G. Thomas, Quantitative histology of Wallerian degeneration; nuclear populations in two nerves of different fibre spectrum, J. Anat., 82:135 (1948).

    Google Scholar 

  6. M. Abercrombie and J. Santler, An analysis of growth in nuclear population during Wallerian degeneration, J. Cell Comp. Physiol., 50:429 (1957).

    Article  CAS  Google Scholar 

  7. W.G. Bradley and A.K. Asbury, Duration of synthesis phase in neurilemma cells in mouse sciatic nerve during degeneration, Exp. Neurol., 26:275 (1970).

    Article  PubMed  CAS  Google Scholar 

  8. P.S. Spencer, R.G. Pellegrino, S. M. Ross, M.J. Politis and M.I. Sabri, The regulation of Schwann cell function in degenerative disorders of the nervous system, in: Molecular Pathology of Nerve and Muscle, A.D. Kidman, Ed., Humana Press, Clifton 3–19 (1983).

    Chapter  Google Scholar 

  9. J.B. Cavanagh and M.F. Gysbers, Dyingback above nerve ligature produced by acrylamide, Acta Neuropathol., 51:169 (1980).

    Article  PubMed  CAS  Google Scholar 

  10. P.S. Spencer and H.H. Schaumburg, Pathobiolgy of neurotoxic axonal degeneration, in: Physiology and Pathobiology of Axons, S.G. Waxman, Ed., Raven Press, New York, pp 265–282 (1978).

    Google Scholar 

  11. J.W. Griffin and D.L. Price, Schwann and glial responses in β, β1 iminodiproprionitrile intoxication. I. Schwann cell and oligodendrocyte in growths. J. Neurocytol., 10:995 (1981).

    Article  PubMed  CAS  Google Scholar 

  12. P.J. Dyck, Experimental hypertrophic neuropathy: pathogenesis of onion-bulb formations, Arch. Neurol., 21:73 (1969).

    CAS  Google Scholar 

  13. T.H. Moss, Segmental demyelination in the peripheral nerves of mice affected by a hereditary neuropathy (Dystonia musculorum), Acta Neuropathol., 53:51 (1981).

    Article  PubMed  CAS  Google Scholar 

  14. C.S. Perkins, A.J. Aguayo and G.M. Bray, Schwann cell multiplication in Trembler mice, Neuropathol. Applied Neurobiol., 7:115 (1981).

    Article  CAS  Google Scholar 

  15. S.M. Hall and N. Gregson, The effects of mitomycin C on the process of regeneration in the mammalian peripheral nervous system, Neuropathol. and Applied Neurobiol., 3:65 (1977).

    Article  Google Scholar 

  16. J.L. Salzer and R.P. Bunge, Studies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury, J. Cell Biol., 84:739 (1980).

    Article  PubMed  CAS  Google Scholar 

  17. J.L. Salzer, R.P. Bunge and L. Glaser, Studies of Schwann cell proliferation. III. Evidence for surface localization of the neurite mitogen, J. Cell Biol., 84:767 (1980).

    Article  PubMed  CAS  Google Scholar 

  18. G. Sobue and D. Pleasure, Adhesion of axolemma fragments to Schwann cells: a signal and target specific process closely linked to axolemmal induction of Schwann cell mitosis, J. Neurosci., 5:379 (1985).

    PubMed  CAS  Google Scholar 

  19. M. M. Ayers and R. McD. Anderson, Onion bulb neuropathy in the Trembler mouse: A model of hypertrophic interstitial neuropathy (Dejerine-Sottas) in man, Acta Neuropathol., 25:54 (1973).

    Article  PubMed  CAS  Google Scholar 

  20. B. Ferzaz, H. Koenig and A. Ressouches, Axonal regeneration in Trembler mouse, a Schwann cell mutant, C.R. Acad. Sci. Paris, 309:377 (1989).

    PubMed  CAS  Google Scholar 

  21. M.J. Politis, N. Sternberger, K. Ederle and P.S. Spencer, Studies on the control of myelinogenesis. IV. Neuronal induction of Schwann cell myelin-specific protein synthesis during nerve fiber regeneration, J. Neurosci., 2:1252 (1982).

    PubMed  CAS  Google Scholar 

  22. P.M. Wood and R.P. Bunge, Evidence that sensory axons are mitogenic for Schwann cells, Nature, 256:662 (1975).

    Article  PubMed  CAS  Google Scholar 

  23. H.L. Koenig, N.A. Do Thi and B. Ferzaz, Proliferation of Trembler mouse Schwann cells in culture and during Wallerian degeneration, Soc. Neurosci., 14:483 (1988).

    Google Scholar 

  24. R.G. Pellegrino and P.S. Spencer, Schwann cell mitosis in response to regenerating peripheral axons in vivo, Brain Res., 341:16 (1985).

    Article  PubMed  CAS  Google Scholar 

  25. A. Krystosek and N.W. Seeds, Peripheral neurons and Schwann cells secrete plasminogen activator, J. Cell Biol., 98:773 (1984).

    Article  PubMed  CAS  Google Scholar 

  26. R. N. Pittman, Release of plasminogen activator and a calcium-dependent metalloprotease from cultured sympathetic and sensory neurons, Devl Biol., 110:91 (1985).

    Article  CAS  Google Scholar 

  27. A. Alvarez-Buylla and J.E. Valinsky, Production of P.A. in cultures of superior cervical ganglia and isolated Schwann cells, Proc. Natl Acad. Sci., USA, 82:3519 (1985).

    Article  PubMed  CAS  Google Scholar 

  28. N. Kalderon, Schwann cell proliferation and localized proteolysis: Expression of P.A. activity predominates in the proliferating cell populations, Proc. Natl. Acad. Sci. USA, 81:7216 (1984).

    Article  PubMed  CAS  Google Scholar 

  29. A. Baron-Van Evercooren, P. Leprince, B. Rogister, P.P. Lefebvre, P. Delree, I. Selak and G. Moonen, Plasminogen activators in developing P.N.S. cellular origin and mitogenic effect, Devl Brain Res., 36:101 (1987).

    Article  Google Scholar 

  30. R.N. Pittman, J. K. Ivins and H.M. Buettner, Neuronal plasminogen activators: Cell surface binding sites and involvement in neurite outgrowth, J. Neurosci., 9:4269 (1989).

    PubMed  CAS  Google Scholar 

  31. J.C. Unkeless, S. Gordon and E. Reich, Secretion of plasminogen activator by stimulated macrophages, J. Exp. Med., 139:834 (1974).

    Article  PubMed  CAS  Google Scholar 

  32. J. Pöllänen, K. Hedman, L.S. Nielsen, K. Danø and A. Vaheri, Ultrastructural localization of plasma membrane-associated urokinasetype plasminogen activator at focal contacts, J. Cell Biol., 106:87 (1988).

    Article  PubMed  Google Scholar 

  33. U. Hedner, Studies on an inhibitor of plasminogen activation in human serum, Thromb. Diath. Haemorrh., 30:414 (1973).

    CAS  Google Scholar 

  34. J. Koenig, D. Hantaz, S. de la Porte, N.A. Do Thi, J.M. Bourre, F. La Chapelle and H.L. Koenig, “In vitro” evidence for a neurite growth-promoting activity in Trembler mouse serum, Int. J. Devl Neurosci., 7:281 (1989).

    Article  CAS  Google Scholar 

  35. A. Bignami, G. Cella and N.H. Chi, Plasminogen activators in rat neural tissues during development and in Wallerian degeneration, Acta Neuropathol., 58:224 (1982).

    Article  PubMed  CAS  Google Scholar 

  36. W.T. Norton, C.F. Brosnan, W. Cammer and E. Goldmuntz, Some aspects of mechanisms of inflammatory demyelination, in: NATO ASI Series H43: Cellular and molecular biology of myelination, G. Jeserich et al., Eds, Springer-Verlag, pp. 101–113 (1990).

    Chapter  Google Scholar 

  37. J.W. Bigbee, J.E. Yoshino and G.H. De Vries, Morphological and proliferative responses of cultured Schwann cells following rapid phagocytosis of a myelin-enriched fraction, J. Neurocytol., 16: 487 (1987).

    Article  PubMed  CAS  Google Scholar 

  38. W. Beuche and R.L. Friede, The role of non-resident cells in Wallerian degeneration, J. Neurocytol., 13:767 (1984).

    Article  PubMed  CAS  Google Scholar 

  39. G. Stoll, J.W. Griffin, C.Y. Li and B.D. Trapp, Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation, J. Neurocytol., 18:671 (1989).

    Article  PubMed  CAS  Google Scholar 

  40. R.N. Pittman and H.M. Buettner, Degradation of extracellular matrix by neuronal proteases, Devl. Neurosci., 11:361 (1989).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. CNRS-URA 1126, Université de Bordeaux I, Avenue des Facultés, 33405, Talence Cedex, France

    Herbert Koenig, Anh Do Thi, Badia Ferzaz & Annie Ressouches

Authors
  1. Herbert Koenig
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  2. Anh Do Thi
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  3. Badia Ferzaz
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  4. Annie Ressouches
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Editor information

Editors and Affiliations

  1. University of California, Berkeley, Berkeley, California, USA

    Paola S. Timiras

  2. Unité 336 INSERM, Université de Montpellier II, Montpellier, France

    Alain Privat

  3. Southern Illinois University, Springfield, Illinois, USA

    Ezio Giacobini

  4. University of North Carolina, Chapel Hill, North Carolina, USA

    Jean Lauder

  5. Health Sciences Center, University of Colorado, Denver, Colorado, USA

    Antonia Vernadakis

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© 1991 Plenum Press, New York

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Koenig, H., Do Thi, A., Ferzaz, B., Ressouches, A. (1991). Schwann Cell Proliferation during Postnatal Development, Wallerian Degeneration and Axon Regeneration in Trembler Dysmyelinating Mutant. In: Timiras, P.S., Privat, A., Giacobini, E., Lauder, J., Vernadakis, A. (eds) Plasticity and Regeneration of the Nervous System. Advances in Experimental Medicine and Biology, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8047-4_21

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  • DOI: https://doi.org/10.1007/978-1-4684-8047-4_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8049-8

  • Online ISBN: 978-1-4684-8047-4

  • eBook Packages: Springer Book Archive

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