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C-6 Glioma Cells of Early Passage Have Progenitor Properties in Culture

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Plasticity and Regeneration of the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 296))

Abstract

Although considerable progress has been made in the last decade in our understanding of the role of glial cells in neuronal development and function, the factors which regulate glia cell growth and function are only recently being investigated (see refs in review Vernadakis, 1988). C-6 glioma cells have provided a useful model to study glial cell properties, glial factors and sensitivity of glial cells to various substances and conditions. In an early study, we reported (Parker et al, 1980) that C-6 glioma cells, 2B clone, exhibited differential enzyme expression with cell passage: the activity of cyclic nucleotide phosphohydrolase (CNP) an enzyme marker for oligodendrocytes (Poduslo and Norton, 1972; Poduslo, 1975) was markedly high and that of glutamine synthetase (GS), an enzyme marker for astrocytes (Martinez-Hernandez et al, 1977; Norenberg and Martinez-Hernandez, 1979) was low in early passages (up to passage 26) and this relationship was reversed in the late passages (beyond passage 70)

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Author information

Author notes

  1. Dimitra Mangoura

    Present address: Dept. of Pediatrics, University of Chicago, Chicago, IL, 60637, USA

  2. Nikos Sakellaridis

    Present address: Dept. of Pharmacology and Toxicology, Northwest Center for Medical Education, University of Indiana School of Medicine, Gary, Indiana, 46408, USA

Authors and Affiliations

  1. Departments of Psychiatry and Pharmacology, University of Colorado School of Medicine, Denver, Colorado, 80262, USA

    Antonia Vernadakis, Susan Kentroti, Chaya Brodie, Dimitra Mangoura & Nikos Sakellaridis

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  1. Antonia Vernadakis
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  2. Susan Kentroti
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  3. Chaya Brodie
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  4. Dimitra Mangoura
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  5. Nikos Sakellaridis
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Editor information

Editors and Affiliations

  1. University of California, Berkeley, Berkeley, California, USA

    Paola S. Timiras

  2. Unité 336 INSERM, Université de Montpellier II, Montpellier, France

    Alain Privat

  3. Southern Illinois University, Springfield, Illinois, USA

    Ezio Giacobini

  4. University of North Carolina, Chapel Hill, North Carolina, USA

    Jean Lauder

  5. Health Sciences Center, University of Colorado, Denver, Colorado, USA

    Antonia Vernadakis

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© 1991 Plenum Press, New York

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Vernadakis, A., Kentroti, S., Brodie, C., Mangoura, D., Sakellaridis, N. (1991). C-6 Glioma Cells of Early Passage Have Progenitor Properties in Culture. In: Timiras, P.S., Privat, A., Giacobini, E., Lauder, J., Vernadakis, A. (eds) Plasticity and Regeneration of the Nervous System. Advances in Experimental Medicine and Biology, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8047-4_18

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  • DOI: https://doi.org/10.1007/978-1-4684-8047-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8049-8

  • Online ISBN: 978-1-4684-8047-4

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