Abstract
This report is an introduction to and brief description of the facilities available for research in biology and related subjects at the Synchrotron Radiation Source (SRS) at the Science and Engineering Research Council (SERC) at Daresbury. The SRS (a 2-GeV accelerator with a critical wavelength of ca. 0.39 nm) and the associated instrumentation and infrastructure has undergone continuous development over the last few years. Further development is still in progress. Among the recently completed projects with a major impact on the exploitation of synchrotron radiation in the general area of biology, biochemistry and biophysics, one must include the implementation of the High Brightness Lattice (HBL), the construction and equipping of the Biology Support Laboratory (BSL), which is jointly funded between the SERC and the Medical Research Council (MRC), and the successful implementation of a time-resolved x-ray diffraction station, incorporating a variety of one- and two-dimensional position sensitive x-ray detector systems. Besides these recent developments, there are now a number of established facilities for time-resolved spectroscopy, X-ray absorption spectroscopy and protein crystallography. The latter two subjects have stations making use of the radiation from a 5-Tesla superconducting wiggler as well as stations taking radiation from the dipole bending magnets.
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Andrews, S. J., Papiz, M. Z., McMeeking, R. F., Blake, A. J., Lowe, B. M., Franklin, K. R., Helliwell, J. R., and Harding, M. M., 1988, Single micro-crystal structure determination with synchrotron radiation, Acta Cryst., B44: 73.
Bordas, J., Mant, G. R., Diakun, G. P., and Nave, C., 1987, X-ray diffraction evidence for the existence of 102.0 and 230.0 nm transverse periodicities in striated muscle, J. Cell Biol., N3: 1311.
Dobson, B. R., Hasnain, S. S., Hart, M., Van der Hoek, M. J., and Van Zuylen, P., 1986, An investigation of the performance of a novel double crystal X-ray monochromator for EXAFS and XANES measurements, J. de Phys., C8: 121.
Hajdu, J., Machin, P. A., Campbell, J. W., Greenhough, T. R., Clifton, I. J., Zurek, S., Gover, S., Johnson, L. N., and Elder, M., 1987, Millisecond x-ray diffraction and the first electron density map from Laue photogaphs of a protein crystal, Nature, 329: 178.
Harris, J. E., Diakun, G. P., Martin, M., Mant, G. R., and Bordas, J., 1988, The low resolution structure of striated muscle, in: “Proceedings of the Second International Conference on Synchrotron Radiation and Biophysics,” England, (To be published).
Hasnain, S. S., 1988, Applications of EXAFS to biochemical systems, in: “Topics in Current Chemistry”, Springer Verlag (In press).
Helliwell, J. R., Greenhough, T. J., Carr, P. D., Rule, S. A., Moore, P. R., Thompson, A. W., and Worgan, J. S., 1982, Central data collection facility for protein crystallography, small angle diffraction and scattering at the Daresbury Laboratory Synchrotron Radiation Source (SRS), England, J. Phys. E: Sci. Instrum., 15: 1363.
Helliwell, J. R., Papiz, M. Z., Glover, I. D., Habash, J., Thompson, A. W., Moore, P. R., Harris, N., Croft, D., and Pantos, E., 1986, The wiggler protein crystallography workstation at the Daresbury SRS: progress and results, Nuc. Inst. and Methods in Phys. Res., A246: 617.
Lewis, R., Sumner, I., Berry, A., Bordas, J., Cabriel, A., Mant, G., Parker, B., Roberts, K., and Worgan, J., 1988, Multiwire x-ray detector system at the Daresbury SRS, Nuc. Inst. and Methods, (in press).
Munro, I. H., and Martin, M. M., 1988, Synchrotron radiation for time-resolved fluorescence studies, in: “Fluorescence Spectroscopy, Vol. II, Biochemical Applications,” J. R. Lakowicz, ed., Plenum, New York (In press).
Munro, I. H., Shaw, D., Jones, G. R., and Martin, M. M., 1985, Time-resolved fluorescence spectroscopy with synchrotron radition, Anal. Instrument., 14: 465.
Nave, C., Diakun, G. P, Bordas, J., 1986, Ultra small angle x-ray diffraction from muscle, Nuc. Inst. and Methods, A246: 609.
Nave, C., Helliwell, J. R., Moore, P. R., Thompson, A. W., Worgan, J. S., Greenall, R. J., Miller, A., Burley, S. K., Bradshaw, J., Pigram, W. J., Fuller, W., Siddons, D. P., Deutsch, M., and Tregear, R. T., (1985), Facilities for solution scattering and fiber diffraction at the Daresbury SRS, J. Appl. Cryst., 18: 396.
Suller, V. P., Corlett, J. N., Dykes, D. M., Hughes, E. A., Poole, M. W., Quinn, P. D., MacKay, J. S., Thomson, S. L., and Walker, R. P., 1988, Performance of the Daresbury SRS with an increased brilliance optics, in: “Proceedings of the First European Particle Accelerator Conference,” Rome, (To be published).
Van der Hoek, M. J., Werner, W., Van Zuylen, P., Dobson, B. R., Hasnain, S. S., Worgan, J. S., and Luijckx, G., 1986, A slitless double crystal monochromator for EXAFS and XANES measurements, Nuc. Inst. and Methods, A256: 380.
Van der Hoek, M. J., Werner, W., Van Zuylen, P., Dobson, B. R., Hasnain, S. S., Worgan, J. S., and Luijckx, G., 1986, A slitless double crystal monochromator for EXAFS and XANES measurements, Nuc. Inst. and Methods, A256: 380.
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© 1989 Plenum Press, New York
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Bordas, J. (1989). Research Facilities for Biology at the Synchrotron Radiation Source at Daresbury Laboratory. In: Sweet, R.M., Woodhead, A.D. (eds) Synchrotron Radiation in Structural Biology. Basic Life Sciences, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8041-2_8
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DOI: https://doi.org/10.1007/978-1-4684-8041-2_8
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