Abstract
More than 25 years have passed since Sir Russell Brock[1] proposed the idea of functional obstruction to left ventricular outlet. Within another year from that date, Donald Teare[2] published the pathological finding encountered in eight hearts with severe but asymmetric hypertrophy affecting the interventricular septum and because of cellular disarray likened it to a “muscular hamartoma”. Spodick and Littman[3] emphasized the malignant nature of idiopathic hypertrophy when symptoms had appeared in a publication about the same time. The physiologic and clinical features of obstructive cardiomyopathy were detailed by Braunwald with the conclusion that there was a dynamic obstruction to left ventricular outlet during systole.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R. Brock, Functional obstruction of the left ventricle (acquired aortic subvalvar stenosis), Guy’s Hospital Report, 221–238 (1957).
D. Teare, Asymmetrical hypertrophy of the heart in young adults, Brit.Heart J., 20: 1–8 (1958).
D. H. Spodick and D. Littman, Idiopathic myocardial hypertrophy, Am.J.Cardiol., 1:610–623 May (1958).
R. Shabetai, Cardiomyopathy, J.Am.Coll.Cardiol., 1: 252–263 (1983).
J. P. Murgo, B. R. Alter, J. F. Dorethy, and S. A. Altobelli, Dynamics of left ventricular ejection in obstructive and non-obstructive cardiomyopathy, J.Clin.Invest., 66: 1369–1382 (1980).
J. F. Goodwin, Prospects and predictions for the cardiomyopathies, Circulation, 50: 210–219 (1974).
P M. Shah, Newer concepts in hypertrophic obstructive cardiomyopathy, JAMA, 242: 1663–1665 (1970).
V. O. Bjork, G. Hultquist, and H. Lodin, Subaortic stenosis produced by an abnormally placed anterior mitral leaflet, J.Thorac.Cardiovasc.Surg., 41: 5, 659–669 (1961).
P. F. Moberg and H. Soderberg, On the pathogenesis of idiopathic hypertrophic subaortic stenosis, J.Cardiovasc.Surg., 4: 602 (1963).
J. E. Edwards, Pathology of left ventricular outflow tract obstruction, Circulation, 10:586–599 (1965).
R. D. Sellers, C. W. Lillehei, and J. E. Edwards, Subaortic stenosis caused by anomalies of the atrioventricular valves, J.Thorac.Cardiovasc.Surg., 48: 2, 289–302 (1964).
W. L. Henry, C. E. Clark, J. M. Griffith, and S. E. Epstein, Mechanism of left ventricular outflow obstruction in patients with obstructive asymmetric septal hypertrophy (Idiopathic hypertrophic subaortic stenosis), Am.J.Cardiol., 35: 337–345 (1975).
J. G. Eillis, O. J. Terneny, W. L. Winters, and R. D. Leachman, Critical role of the mitral valve leaflet in hypertrophic subaortic stenosis and amelioration of the disease by mitral valve replacement, Chest, 59: 4. 378–382 (1971).
H. B. Schumacker and H. King, New operative approach in the management of hypertrophie subaortic stenosis, J.Thorac. Cardiovasc.Surg., 49: 3, 497–503, March (1965).
D. A. Cooley, R. R. Grace, D. C. Wukasch, and R. D. Leachman, Replacement and/or repair of the mitral valve as treatment of idiopathic hypertrophic subaortic stenosis, Cardiovasc.Dis., 3: 4, 381–393 (1976).
Z. Krajcer, F. Orzan, L. W. Pechacek, E. Garcia, and R. D. Leachman, Early systolic closure of the aortic valve in patients with hypertrophic subaortic stenosis and discrete subaortic stenosis: Correlation with preoperative and postoperative hemodynamics, Am.J.Cardiol., 41: 823 (1978).
B. J. Maron, W. H. Merrill, P. A. Freier, K. M. Kent, S. E. Epstein, and A. G. Morrow, Long-term clinical course and symptomatic status of patients after operation for hypertrophic subaortic stenosis, Circulation, 57: 6, 1205–1213 (1978).
R. L. Reis, M. R. Bolton, J. F. King, D. M. Pugh, M. I. Dunn, and D. T. Mason, Anterior-superior displacement of papillary muscles producing obstruction and mitral regurgitation in idiopathic hypertrophic sub-aortic stenosis, Circulation, 49 and 50:Suppl.II, 181–188 (1974).
R. D. Leachman and Z. Krajcer, Significant reduction of asymmetrical septal hypertrophy following mitral valve replacement in patients with idiopathic hypertrophic subaortic stenosis, Abs.Circulation, 64:Suppl.IV: 314 ( 1980.
A. G. Adelman, M. J. McLoughlin, and Y. Marquis, et al., Left ventricular cineangiographic observations in muscular sub-aortic stenosis, Am.J.Cardiol., 24: 689 (1969).
M. S. Gotsman and B. S. Lewis, Left ventricular volumes and compliance in hypertrophic cardiomyopathy, Chest, 66: 498–505 (1974).
J. E. Sanderson, D. G. Gibson, D. J. Brown, and J. F. Goodwin, Left ventricular filling in hypertrophic cardiomyopathy: An angiographie study, Brit.Heart J., 39: 661–670 (1977).
P. Hanrath, D. G. Mathey, R. Siegart, and W. Bleifeld, Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: An echocardiographic study, Am.J.Cardiol., 45: 15–23 (1980).
A. G. Adelman, E. D. Wigle, N. Ranganathan, G. D. Webb, B. S. L. Kidd, W. G. Bigelow, and M. D. Silber, The clinical course in muscular subaortic stenosis: A retrospective and prospective study of 60 hemodynamically proved cases, Ann.Int.Med., 77: 515–525 (1972).
P. Hanrath, D. G. Mathey, P. Kremer, F. Sonntag, and W. Bleifeld, Effect of verapamil on left ventricular isovolumic relaxation time and regional left ventricular filling in hypertrophie cardiomyopathy, Am.J.Cardiol., 45: 1258 (1980).
B. Lorell, W. Paulus, and W. Grossman et al., Improved diastolic compliance on hypertrophie cardiomyopathy treated with nifedipine, Abs. 53rd Scientific Session, Am.Heart Assoc., 111: 317 (1980).
S. E. Epstein, W. L. Henry, and C. E. Clark et al., Asymmetric septal hypertrophy, Ann.Int.Med., 81: 650–680 (1974).
J. S. Borer, S. L. Bacharach, and M. V. Green, et al., Effect of septal myotomy and myomectomy on left ventricular function at rest and during exercise in patients with IHSS, Circulation, Suppl:60, I-82–87 (1979).
R. D. Leachman and Z. Krajcer, Surgical versus medical therapy in patients with hypertrophic cardiomyopathy and mid-cavity obliteration, Abstract submitted to 56th Scientific Sessions Meeting, Am.Heart Assoc., November (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Leachman, R.D. (1985). Ventricular Dysfunction in Hypertrophic Cardiomyopathy. In: Raineri, A., Leachman, R.D., Kellermann, J.J. (eds) Assessment of Ventricular Function. Ettore Majorana International Science Series, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8003-0_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8003-0_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8005-4
Online ISBN: 978-1-4684-8003-0
eBook Packages: Springer Book Archive