Abstract
Anti-idiotype antibodies that recognize a common human idiotype present on antibodies to hepatitis B surface antigen (anti-HBs) from individuals naturally infected by hepatitis B virus (HBV) and an interspecies idiotype on anti-HBs produced by active immunization with hepatitis B surface antigen (HBsAg) were used in vivo to modulate idiotype networks in mice. Injection of anti-idiotype antibodies without subsequent HBsAg stimulation induced an anti-HBs response. The anti-idiotype-induced anti-HBs recognized the group-specific a determinant(s) of HBsAg, which has been shown to be responsible for induction of protective immunity to HBV in both chimpanzees and humans. In addition, the anti-HBs expressed an interspecies idiotype which is shared by humans naturally infected with HBV. Prior inoculation of mice with alum-adsorbed anti-idiotype potentiated the immune response to a subsequent inoculation with either native HBsAg particles or with a synthetic HBsAg peptide. These data suggest the potential use of anti-idiotype antibodies as a vaccine or vaccine potentiator for HBV.
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Abbreviations
- Anti-HBs:
-
antibodies to hepatitis B surface antigen
- Anti-Id:
-
anti-idiotype antibodies
- HBsAg:
-
hepatitis B surface antigen
- HBV:
-
hepatitis B virus
- PFC:
-
plaque forming cells
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© 1985 Plenum Press, New York
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Kennedy, R.C., Dreesman, G.R. (1985). Antigen Mimicry by Anti-Idiotype Antibodies That Recognize a Common Anti-Hepatitis B Surface Antigen Idiotype. In: Atassi, M.Z., Bachrach, H.L. (eds) Immunobiology of Proteins and Peptides—III. Advances in Experimental Medicine and Biology, vol 185. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7974-4_9
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DOI: https://doi.org/10.1007/978-1-4684-7974-4_9
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