Abstract
Bordetella pertussis and other Bordetella species cause respiratory infections in humans and in a variety of animals. Clinical isolates of B. pertussis have multiple virulence factors, several of which have been reported to induce protective immunity. Using cell surface iodination techniques and monoclonal antibody immunoblots we have identified several proteins which are exposed on the surface of B. pertussis cells, including the filamentous hemagglutinin and outer membrane proteins 91, 18, and 15. Protein 91 is unique to virulent B. pertussis strains. Antibodies to protein 18 are found in convalescent serum of both humans and mice recovering from infection with B. pertussis.
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References
Arai, H., and Sato. Y., 1976, Separation and characterization of two distinct hemagglutinins contained in the purified leukocytosispromoting factor from Bordetella pertussis, Biochem. Biophys. Acta, 444: 765–782.
Ashworth, L., Irons, L., and Dowsett, A., 1982, Antigenic relationship between serotype-specific agglutinogen and fimbriae of Bordetella pertussis, Infect. Immun., 37: 1278–1281.
Field, L., and Parker, C., 1979, Differences observed between fresh isolates of Bordetella pertussis and their laboratory passaged derivatives, in: “International Symposium on Pertussis,” C. Manclark, and J. Hill, eds., pp. 124–132, DHEW Publication No. (NIH) 79–1830, Washington, D.C.
Frank, D., and Parker, C., 1984a, Isolation and characterization of monoclonal antibodies to Bordetella pertussis, J. Biologic. Standard., 12: (in press).
Frank, D., and Parker, C., 1984b, Interaction of monoclonal antibodies with pertussis toxin and its subunits, Infect. Immun., 46: (in press).
Goodnow, R., 1980, Biology of Bordetella bronchiseptica, Microbiol. Rev., 44: 722–738.
Hewlett, E., and Wolff, J., 1976, Soluble adenylate cyclase from the culture medium of Bordetella pertussis, J. Bacteriol., 127: 890–898.
Lacey, B. W., 1960, Antigenic modulation of Bordetella pertussis, J. Hyg., 58: 57–93.
Markwell, M., and Fox, C., 1978, Surface-specific iodination of membranes of viruses and eucaryotic cells using 1,3,4,6tetrachloro-3,6-diphenylglycouril, Biochem., 17: 4807–4817.
Parton, R., and Wardlow, A. C., 1975, Cell-envelope proteins of Bordetella pertussis, J. Med. Microbiol., 8: 47–57.
Pittman, M., 1970, Bordetella pertussis: bacterial and host factors in the pathogenesis and prevention of whooping cough, in: “Infectious Agents and Host Reactions,” S. Mudd, ed., pp. 239–270, W. B. Saunders Company, Philadelphia.
Pusztai, S., and Joo, I., 1967, Influence of nicotinic acid on the antigenic structure of Bordetella pertussis, Ann. Immunol. Hung., 10: 63–67.
Sato, Y., Izumiya, K., Sato, H., Cowell, J., and Manclark, C., 1981, Role of antibody to leukocytosis-promoting factor hemagglutinin and to filamentous hemagglutinin in immunity to pertussis, Infect. Immun., 31: 1223–1231.
Schneider, D., and Parker, C., 1982, Effect of pyridines on phenotypic properties of Bordetella pertussis, Infect. Immun., 38: 548–553.
Standfast, A., 1951, The phase I of Haemophilus pertussis, J. Gen. Microbiol., 5: 531–545.
Wardlow, A. C., and Parton, R., 1983, Bordetella pertussis toxins, Pharmac. Ther., 19: 1–53.
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© 1985 Plenum Press, New York
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Parker, C.D., Armstrong, S.K., Frank, D.W. (1985). Surface Antigens of Bordetella Pertussis . In: Atassi, M.Z., Bachrach, H.L. (eds) Immunobiology of Proteins and Peptides—III. Advances in Experimental Medicine and Biology, vol 185. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7974-4_7
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DOI: https://doi.org/10.1007/978-1-4684-7974-4_7
Publisher Name: Springer, Boston, MA
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