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Endogenous Excitotoxins as Possible Mediators of Ischemic and Hypoglycemic Brain Damage

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Excitatory Amino Acids and Epilepsy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 203))

Abstract

Hypoglycemia and cerebral ischemia are conditions associated with a vast number of complicated clinical situations (Marks, 1972; Graham, 1985). If severe, both hypoglycemia and cerebral ischemia inevitably lead to irreversible neuronal damage (Brierley, 1976). Similarly as in epilepsy, the damage incurred following hypoglycemia and ischemia is distributed to specific vulnerable areas of the brain. However, the distribution of the damage differs between these three conditions (Siesjö and Wieloch, 1986), suggesting that at least in some aspects different pathophysiological mechanisms prevail. Although this selective neuronal damage has been known for several decades (Spielmeyer, 1925), its pathophysiological and molecular mechanisms are largely elusive.

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Author information

Authors and Affiliations

  1. Laboratory for Experimental Brain Research, University Hospital, University of Lund, S-221 85, Lund, Sweden

    T. Wieloch

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  1. T. Wieloch
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Editors and Affiliations

  1. Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Robert Schwarcz

  2. INSERM-U29, Hôpital de Port-Royal, Paris, France

    Yehezkel Ben-Ari

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© 1986 Plenum Press, New York

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Wieloch, T. (1986). Endogenous Excitotoxins as Possible Mediators of Ischemic and Hypoglycemic Brain Damage. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_9

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  • DOI: https://doi.org/10.1007/978-1-4684-7971-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7973-7

  • Online ISBN: 978-1-4684-7971-3

  • eBook Packages: Springer Book Archive

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