Abstract
In attempting to understand the relationship between brain damage and recurrent seizures, Hughlings Jackson, as early as 1872, pioneered the concept of hyperexcitable tissue adjacent to frontal cortex tumors or infarcts (Jackson, 1931a). He adopted the same explanation to partial complex seizures in which there was an intellectual aura, only slight movements and a ‘dreamy state’ defect in consciousness (Jackson, 1931b). These partial seizures were localized to the temporal lobe when the necropsy reports identified a temporo-sphenoidal tumor in one epileptic (Jackson and Beevor, 1890) and a softening of the uncinate gyrus in another (Jackson and Coleman, 1898). These cases confirmed earlier correlations of partial seizures and temporal lobe pathologies (Sanders, 1874; Hamilton, 1882; Anderson, 1887). Hence, the Jacksonian concept of hyperexcitable tissue adjacent to neocortical damage was accepted; however, that concept was not extended to the mesial temporal lobe (archicortex), where damage was well -established in epileptics.
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© 1986 Plenum Press, New York
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Babb, T.L. (1986). Metabolic, Morphologic and Electrophysiologic Profiles of Human Temporal Lobe Foci: An Attempt at Correlation. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_8
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DOI: https://doi.org/10.1007/978-1-4684-7971-3_8
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