Skip to main content

Selective and Non-Selective Seizure Related Brain Damage Produced by Kainic Acid

  • Chapter
Excitatory Amino Acids and Epilepsy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 203))

Abstract

Parenteral or intracerebral administration of the potent excitatory amino acid kainic acid (KA) produces a seizure and brain damage syndrome in which limbic structures play a central role. This has been investigated extensively, notably since it constitutes a useful animal model of human temporal lobe epilepsy. In the present report, I shall briefly discuss a number of aspects concerning these actions of KA — in particular the effects produced by parenteral injections of the toxin (e.g., Ben-Ari, 1985 for a recent review).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Assaf, S.Y., and Chung S., 1984, Release of endogenous Zn2+ from brain tissue during activity, Nature 308: 734.

    CAS  Google Scholar 

  • Ashwood, T.J., Lancaster, B., and Wheal, H.V., 1983, Bursting activity in the kainic acid (KA) lesioned rat hippocampus is associated with a reduction in GABA mediated inhibition, J. Physiol. 336:59P.

    Google Scholar 

  • Ben-Ari, Y., Krnjevié, K., and Reinhardt, W., 1979, Hippocampal seizures and failure of inhibition, Can J. Physiol. Pharmacol. 57:1462.

    Google Scholar 

  • Ben-Ari, Y., Tremblay, E., Riche, D., Ghilini, G., and Naquet, R., 1981, Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline and pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy, Neuroscience 6: 1361.

    CAS  Google Scholar 

  • Ben-Ari, Y., 1985, Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy, Neuroscience 14: 375.

    CAS  Google Scholar 

  • Berger, M., and Ben-Ari, Y., 1983, Autoradiographic visualization of 3H kainic acid receptor subtypes in the rat hippocampus, Neurosci. Lett. 39:237.

    Google Scholar 

  • Charton, G., Rovira, C., Ben-Ari, Y., 4nd Leviel, V., 1985, Spontaneous and evoked release of endogenous Zn + in the hippocampal mossy fiber zone of the rat in situ, Exp. Brain Res. 58:202.

    Google Scholar 

  • Chung, S.H., and Johnson, M.S. 1983, Divalent transition-metal ions (Ca2+ and Zn2+) in the brains of epileptogenic and normal mice, Brain Res. 280:323.

    Google Scholar 

  • Fisher, R.A., and Alger, B.E., 1984, Electrophysiological action of kainic acid (KA) induced epileptiform activity in the rat hippocampal slice, J. Neurosci. 4:1312.

    Google Scholar 

  • Franck, J.E., and Schwartzkroin, P.A., 1983, Kainate lesioned hippocampi become epileptogenic, Soc. Neurosci. Abstr. 9:908.

    Google Scholar 

  • Haug, F.M.S., 1967, Electron microscopical localization of the zinc in hippocampal mossy fiber synapses by a modified sulphide silver procedure, Histochemie 8: 355.

    CAS  Google Scholar 

  • Haug, F.M.S., 1973, Heavy metals in the brain. A light microscopic study

    Google Scholar 

  • of the rat with Timm’s sulphide silver method. Methodological considerations and cytological and regional staining patterns, Adv, Anat. Embryol. Cell Biol. 47:1.

    Google Scholar 

  • Jande, S.S., Maler, L., and Lawson, E.M., 1981, Immunohistochemical mapping of vitamin D dependent calcium binding protein in brain, Nature 294: 765.

    CAS  Google Scholar 

  • Krnjevic, K. Morris, M.E., and Reiffenstein, R.J., 1980, Changes in extra-cellular Ca2+ and K+ activity accompanying hippocampal discharges

    Google Scholar 

  • Can. J. Physiol. Pharmacol. 58:579.

    Google Scholar 

  • London, E.D., and Coyle, J.T., 1979, Specific binding of 3H kainic acid

    Google Scholar 

  • to receptor sites in rat brain, Molec. Pharmacol. 15:492.

    Google Scholar 

  • Lothman, E.W., and Collins, C.R., 1981, Kainic acid-induced limbic motor

    Google Scholar 

  • seizures: metabolic, behavioral, electroencephalographic and neuro-

    Google Scholar 

  • pathological correlates, Brain Res. 218:299.

    Google Scholar 

  • Madison, D.V., and Nicoll, R.A., 1984, Control of the repetitive discharges of rat CA1 pyramidal neurons in vitro, J. Physiol. 354:319.

    Google Scholar 

  • Monaghan, D.T., and Cotman, C.W., 1982, The distribution of 3H kainic acid binding sites in rat CNS as determined by autoradiography, Brain Res., 252: 91.

    CAS  Google Scholar 

  • Nadler, J.V., and Cuthbertson, G.J., 1980, Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways, Brain Res. 195: 47.

    CAS  Google Scholar 

  • Nadler, J.V., Evenson, D.A., and Cuthbertson, G.J. 1981, Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons, Neuroscience 6: 2505.

    CAS  Google Scholar 

  • Nadler, J.V., Evenson, D.A., and Smith, E.M., 1981, Evidence from lesion studies for epileptogenic and non-epileptogenic neurotoxic interactions between kainic acid and excitatory innervation, Brain Res. 205: 405.

    CAS  Google Scholar 

  • Nitecka, L., Tremblay, E., Charton, G., Bouillot, J.P., Berger, M., and Ben-Ari, Y., 1984, Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae, Neuroscience 13: 1073.

    Article  CAS  Google Scholar 

  • Olney, J.W., Fuller, T.A., and De Gubareff, T., 1981, Folates have kainate like neurotoxicity, Nature 292: 165.

    CAS  Google Scholar 

  • Pinard, E., Tremblay, E., and Seylaz, J., 1984, Blood flow compensates oxygen demand in the vulnerable CA3 region of the hippocampus during kainate-induced seizures, Neuroscience 13: 1039.

    CAS  Google Scholar 

  • Robinson, J.H., and Deadwyler, S.A., 1981, Kainic acid produces depolarization of CA3 pyramidal cells in the in vitro hippocampal slice, Brain Res., 221: 117.

    CAS  Google Scholar 

  • Rothman, S.M., 1985, The neurotoxicity of excitatory amino acids is produced by passive chloride influx, J. Neurosci. 6:1483.

    Google Scholar 

  • Scheibel, M.E., and Scheibel, A.B., 1973, Hippocampal pathology in temporal lobe epilepsy. A Golgi survey, in: Epilepsy. Its Phenomenon in Man M.A.B. Brazier, ed., Academic Press, New York, p. 311.

    Google Scholar 

  • Schwartz, R., and Fuxe, K., 1979, 3H kainic acid binding: relevance for evaluating the neurotoxicity of kainic acid, Life Sci. 24: 1471.

    Google Scholar 

  • Schwob, J.E., Fuller, T., Price, J., and Olney, J.W., 1980, Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study, Neuroscience 5: 991.

    PubMed  CAS  Google Scholar 

  • Sloviter, R.S., and Damiano, B.P., 1981, On the relationship between kainic acid-induced epileptiform activity and hippocampal neuronal damage, Neuropharmacology 20: 1003.

    CAS  Google Scholar 

  • Sloviter, R.S., 1983, Epileptic brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies, Brain Res. Bull. 10:675.

    Google Scholar 

  • Sperk, G., Lassmann, H., Baran, H., Kish, S.J., Seitelberger, F., and Hornykiewicz, 0., 1983, Kainic acid induced seizures: neurochemical and histopathological changes, Neuroscience 10: 1301.

    Google Scholar 

  • Tauck, D.L., and Nadler, J.V., 1985, Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid treated rats

    Google Scholar 

  • J. Neurosci.,5:1016.

    Google Scholar 

  • Tremblay, E., Berger, M., Nitecka, L., Cavalheiro, E., and Ben-Ari, Y., 1984, A multidisciplinary study of folic acid neurotoxicity: interactions with kainate binding sites and relevance to the aetiology of epilepsy, Neuroscience 12:569.

    Google Scholar 

  • Tremblay, E., Nitecka, L., Berger, M.L., and Ben-Ari, Y., 1984, Maturation of kainic acid seizure-brain damage syndrome in the rat. I. Clinical, electrographic and metabolic observations, Neuroscience 13: 1051.

    CAS  Google Scholar 

  • Tremblay, E., Repressa, A., and Ben-Ari, Y., 1985, Autoradiographic local- ization of KA binding sites in human hippocampi, Brain Res. 343: 378.

    CAS  Google Scholar 

  • Unnerstall, J.R., anq Wamsley, J.K., 1983, Autoradiographic localization of high-affinity H kainic acid binding sites in the rat forebrain, Eur. J. Pharmacol. 86:361.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Ben-Ari, Y., Repressa, A., Tremblay, E., Nitecka, L. (1986). Selective and Non-Selective Seizure Related Brain Damage Produced by Kainic Acid. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_49

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7971-3_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7973-7

  • Online ISBN: 978-1-4684-7971-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics