Abstract
The apparent ubiquity of both excitatory and inhibitory amino acid receptors in the mammalian central nervous system is now well established. Despite the passage of approximately 23 years since the inception of γ-aminobutyric acid (GABA) and glutamate receptors (Curtis and Watkins, 1963; Krnjevic and Phillis, 1963), these receptor sites and their associated ‘ion channels’ have proved difficult to study quantitatively, mainly because of limited pharmacological accessibility and complicated tissue topography.
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References
Ashwood, T.J., Collingridge, G.L., Herron, C.E., and Wheal, H.V., 1984, Rectification of somatic y-aminobutyric acid ( GABA) responses in rat hippocampal slices, J. Physiol., 357: 15.
Ault, B., Evans, R.H., Francis, A.A., Oakes, D.J., and Watkins, J.C., 1980, Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations, J. Physiol., 307: 413.
Aviv, H., and Leder, P., 1972, Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose, Proc, Natl. Acad. Sci. USA, 69: 1408.
Barnard, E.A., Miledi, R., and Sumikawa, K., 1982, Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes, Proc. Roy. Soc. Lond. B., 215: 241.
Barnard, E.A., Beeson, D., Bilbe, G., Brown, D.A., Constanti, A., Houamed, K., and Smart, T.G., 1984, A system for the translation of receptor messenger RNA and the study of the assembly of functional receptors, J. Receptor Res., 4: 681.
Chirgwin, J.M., Przybyla, A.E., McDonald, R.J., and Rutter, W.J., 1979, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry, 18: 5294.
Curtis, D.R., and Watkins, J.C., 1963, Acidic amino acids with strong excitatory actions on mammalian neurones, J, Physiol., 166: 1.
Curtis, D.R., Duggan, A.W., and Johnston, G.A.R., 1971, The specificity of strychnine as a glycine antagonist in the mammalian spinal cord, Exp. Brain Res., 12: 547.
Dumont, J.N., 1972, Oogenesis in Xenopus laevis ( Daudin) I, J. Morphol., 136: 153.
Gundersen, C.B., Miledi, R., and Parker, I., 1984a, Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes, Nature, 308: 421.
Gundersen, C.B., Miledi, R., and Parker, I., 1984b, Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes, Proc. Rov, Soc. Lond. B., 221: 127.
Gundersen, C.B., Miledi, R., and Parker, I., 1984c, Properties of human brain glycine receptors expressed in Xenopus oocytes, Proc. Roy. Soo. Lond. B., 221: 235.
Gurdon, J.B., Lane, C.D., Woodland, H.R., and Marbaix, G., 1971, Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells, Nature, 233: 177.
Houamed, K.M., Bilbe, G., Smart, T.G., Constanti, A., Brown, D.A., Barnard, E.A., and Richards, B.M., 1984, Expression of functional GABA, glycine and glutamate receptors in Xenopus oocytes injected with rat brain mRNA, Nature, 310: 318.
Krnjevié, K., and Phillis, J.W., 1963, Iontophoretic studies of neurones in the mammalian cerebral cortex, J. Physiol., 165: 274.
Kusano, K., Miledi, R., and Stinnakre, J., 1982, Cholinergie and catecholaminergic receptors in the Xenopus oocyte membrane, J. Physiol., 328: 143.
Miledi, R., Parker, I., and Sumikawa, K., 1982, Synthesis of chick brain GABA receptors by frog oocytes, Proc. Roy. Soc. Lond. B., 216: 509.
Miledi, R., and Parker, I., 1984, Chloride current induced by injection of calcium into Xenopus oocytes, J, Physiol., 357: 173.
Mishina, M., Kurosaki, T., Tobimatsu, T., Morimoto, Y., Noda, M., Yamamoto, T., Terao, M., Lindstrom, J., Takahashi, T., Kuno, M., and Numa, S., 1984, Expression of functional acetylcholine receptor from cloned cDNAs, Nature, 307: 604.
Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., and Prochiantz, A., 1984, Magnesium gates glutamate-activated channels in mouse central neurones, Nature, 307: 462.
Sigel, E., Stephenson, F.A., Mamalaki, C., and Barnard, E.A., 1983, A y-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex. Purification and partial characterization, J, Biol. Chem., 258: 6965.
Simmonds, M.A., 1982, Classification of some GABA antagonists with regard to site of action and potency in slices of rat cuneate nucleus, Eur. J. Pharmacol „ 80: 347.
Smart, T.G., Constanti, A., Bilbe, G., Brown, D.A., and Barnard, E.A., 1983, Synthesis of the functional chick brain benzodiazepine barbiturateGABA receptor complex in mRNA injected Xenopus oocytes, Neurosci, Lett., 40: 55.
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© 1986 Plenum Press, New York
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Smart, T.G. et al. (1986). Expression of Vertebrate Amino Acid Receptors in Xenopus Oocytes. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_41
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DOI: https://doi.org/10.1007/978-1-4684-7971-3_41
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