Abstract
What defines the abnormality of epileptic tissue? What constitutes an epileptic focus? Experimental studies have been carried out for many years to try and answer these questins, and a large number of alterations have been proposed as basic to generation of epileptiform activity (Jasper et al., 1969; Lockard and Ward, 1980; Schwartzkroin and Wheal, 1984; DelgadoEscueta et al., 1986). Yet, our real information about the abnormalities intrinsic to the epileptic condition remains limited. In studying potential causes of abnormal cell electrical activity, we have become familiar with many of the normal properties of neocortical and hippocampal neurons, but have not been able to define the essential nature of the epileptic defect. Morphological, pharmacological, biochemical, and electrophysiological features have been suggested which could be involved in generation of epileptiform activity (Westrum et al., 1964; Heinemann et al., 1977; Woodbury and Kemp, 1977; French and Siggins, 1980; Schwartzkroin and Wyler, 1980; Lux and Heinemann, 1982; Ribak et al., 1982;. Dudek et al., 1983; Grisar et al., 1983; Scheibel et al., 1983; Schwartzkroin, 1983; DeLorenzo, 1984; Johnston and Brown, 1984; Somjen, 1984). For most of these, it remains unclear whether the abnormality is present before, and is responsible for, the development of epileptiform activity, or whether these abnormalities are produced as a result of abnormal electrical activity in the brain. It is this issue of defining causal, rather than correlative features of epileptogenesis that has been so difficult in epilepsy research. The drive for such causality has led to the establishment of a host of animal model systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ajmone-Marsan, C., 1969, Acute effects of topical epileptogenic agents, in: Basic Mechanisms of the Epilepsies, H.H. Jasper, A.A. Ward, Jr., and A. Pope, eds., Little, Brown and Company, Boston, p. 299.
Bakay, R.A.E., and Harris, A.B., 1981, Neurotransmitter, receptor and biochemical changes in monkey cortical epileptic foci, Brain Res., 206:387.
Berger, M., and Ben-Ari, Y., 1983, Autoradiographie visualization of 3Hkainic acid receptor subtypes in the rat hippocampus, Neurosci. Lett., 39:237.
Bird, S.J., and Aghajanian, G.K., 1975,. Denervation supersensitivity in the cholinergie septo-hippocampal pathway: a microiontophoretic study, Brain Res., 100: 355.
Cavalheiro, E.A., Riche, D.A., and Le Gal La Salle, G., 1982, Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures, Electroenceph. Clin. Neurophysiol., 53:581.
Delgado-Escueta, A.V., Ward, A.A., Jr., Woodbury, D.M., and Porter, R., eds., 1986, Basic Mechanisms of the Epilepsies, Raven Press, New York, in press.
DeLorenzo, R.J., 1984, Calmodulin systems in neuronal excitability: a molecular approach to epilepsy, Annals Neurol., 16 (Suppl): 8104.
Dingledine, R., and Gjerstad, L., 1980, Reduced inhibition during epileptiform activity in the in vitro hippocampal slice, J. Phvsiol., 305:297.
Dingledine, R., and Langmoen, I.A., 1980, Conductance changes and inhibitoryactions of hippocampal recurrent IPSPs, Brain Res., 185: 277.
Dingledine, R., ed., 1984, Brain Slices, Plenum Press, New York.
Dudek, F.E., Andrew, R.D., MacVicar, B.A., Snow, R.W., and Taylor, C.P., 1983, Recent evidence for and possible significance of gap junctions and electrotonic synapses in the mammalian brain, in: Basic Mechanisms of Neuronal Hvperexcitability, H.H. Jasper and N.M. VanGelder, eds., Alan R. Liss, New York, p. 31.
Franck, J.E., and Schwartzkroin, P.A., 1985, Do kainate-lesioned hippocampi become epileptogenic? Brain Res., 329: 309.
French, E.D., and Siggins, G.P., 1980, An iontophoretic survey of opioid peptide actions in the rat limbic system: in search of opiate epileptogenic mechanisms, Reg. Pept., 1:127.
Gloor, P., 1984, Electrophysiology of generalized epilepsy, in: Electrophysiolqgy of Epilepsy, P.A. Schwartzkroin and H.V. Wheal, eds., Academic Press, New York, p. 107.
Grisas, T., Franck, G., and Delgado-Escueta, A.V., 1983, Glial contribution to seizures: K+ activation of (Na+, K+) -ATPase in bulk isolated glial cells and synaptosomes of epileptogenic cortex, Brain Res., 261: 75.
Heinemann, U., Lux, H.D., and Gutnick, M.J., 1977, Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat, Exp. Brain Res., 27:237.
Jasper, H.H., Ward, A.A., Jr., and Pope, A., eds., 1969, Basic Mechanisms of the Epilepsies, Little, Brown and Company, Boston.
Johnston, D., and Brown, T.H., 1984, Mechanisms of neuronal burst generation, in: Electrophysiology of Epilepsy, P.A. Schwartzkroin and H.V. Wheal, eds., Academic Press, London, p. 277.
Karnushina, I., Susuki, R., Padgett, W., and Daly, J.W., 1983, Degeneration of CA1 neurons in hippocampus after ischemia in mongolian gerbils: cyclic AMP systems, Brain Res., 268: 87.
Knowles, W.D., Traub, R.D., Wong, R.K.S., and Miles, R., 1985, Properties of neural networks: experimentation and modeling of the epileptic hippocampal slice, TINS, 8: 73.
Lockard, J.S., and Ward, A.A., Jr., eds., 1980, Epilepsy: A Window to Brain Mechanisms, Raven Press, New York.
Lux, H.D., and Heinemann, U., 1982, Consequences of calcium electrogenesis for the generation of paroxysmal depolarisation shift, in: Epilepsy and the Motor System, E.J. Speckmann and H. Elger, eds., Urban and Schwarzenberg, Munich, p. 101.
Lux, H.D., Heinemann, U., and Dietzel, I., 1986, Ionic changes and alterations in the size of the extracellular space during epileptic activity, in: Basic Mechanisms of the Epilepsies, A.V. Delgado-Escueta, A.A. Ward, Jr., D.M. Woodbury, and R. Potter, eds., Raven Press, in press.
McNamara, J.O., Galloway, M.T., Rigsbee, L.C., and Shin, C., 1984, Evidence implicating substantia nigra in regulation of kindled seizure thresholdJ. Neurosci., 4:2410.
Nadler, J.V., Perry, B.W., Gentry, C., and Cotman, C.W., 1980,. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid, J. Comp. Neurol., 192:333.
Nitecka, L., Tremblay, E., Charton, G., Bouillot, J.P., Berger, M.L., and Ben-Ari, Y., 1984, Maturation of kainic acid seizure-brain damage syndrome in the rat. H. Histopathological sequelae, Neuroscience, 13: 1073.
Pollen, D.A., and Trachtenberg, M.C., 1970, Neuroglia: gliosis and focal epilepsy, Science, 167: 1252.
Prince, D.A., 1968, The depolarization shift in ’epileptic’ neurons, Exp. Neurol., 21:467.
Prince, D.A., 1978, Neurophysiology of epilepsy, Ann. Rev. Neurosci., 1:395.
Prince, D.A., and Wong, R.K.S., 1981, Human epileptic neurons studied in vitro, Brain Res., 210:323.
Purpura, D.P., Penry, J.K., Tower, D., Woodbury, D.M., and Walter, R., eds., 1972, Experimental Models of Epilepsy, Raven Press, New York.
Ribak, C.E., Bradburne, R.M., and Harris, A.B., 1982, A preferential loss of GABAergic symmetric synapses in epileptic foci: a quantitative ultrastructural analysis of monkey neocortex, J. Neurosci., 2:1725.
Savage, D.D., Werling, L.L., Nadler, J.V., and McNamara, J.0., 1984, Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling, Brain Res., 307: 332.
Scheibel, A.B., Paul, L., and Fried, I., 1983, Some structural substrates of the epileptic state, in: Basic Mechanisms of Neuronal Hyperexcitabilitv., H.H. Jasper and N.M. VanGelder, eds., Alan R. Liss, New York, p. 109.
Schwartzkroin, P.A., and Prince D.A., 1976, Microphysiology of human cerebral cortex studied in vitro, Brain Res., 115:497.
Schwartzkroin, P.A., and Prince, D.A., 1980, Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity, Brain Res., 183: 61.
Schwartzkroin, P.A., and Wyler, A.R., 1980, Mechanisms underlying epileptiform burst discharge, Ann. Neurol., 7:95.
Schwartzkroin, P.A., 1981, To slice or not to slice, in: Electrophvsiology of Isolated Mammalian CNS Preparations, G.A. Kerkut and H. V. Wheal,eds., Academic Press, London, p. 15.
Schwartzkroin, P.A., 1983, Local circuit considerations and intrinsic neuronal properties involved in hyperexcitability and cell synchronization, in: Basic Mechanisms of Neuronal Hyperexcitability, H.H. Jasper and N.M. VanGelder, eds., Alan R. Liss, New York, p. 75.
Schwartzkroin, P.A., Turner, D.A. Knowles, W.D., and Wyler, A.R., 1983, Studies of human and monkey ’epileptic’ neocortex in the in vitro slice preparation, Ann. Neurol., 13: 249.
Schwartzkroin, P.A., and Knowles, W.D., 1984, Intracellular study of human epileptic cortex; in vitro maintenance of epileptiform activity?, Science, 223: 709.
Schwartzkroin, P.A., and Wheal, H.V., eds., 1984, Electrophysiology of Epilepsy, Academic Press, London.
Sharpless, S.K., 1969, Isolated and deafferented neurons: disuse supersensitivity, in: Basic Mechanisms of the Epilepsies, H.H. Jasper, A.A. Ward, Jr., and A. Pope, eds., Little, Brown and Company, Boston, p. 329.
Somjen, G.G., 1984, Interstitial ion concentration and the role of neuroglia in seizures, in: Electrophvsiologv of Epilepsy, P.A. Schwartzkroin and H.V. Wheal, eds., Academic Press, London, p. 303.
Sperk, G., Lassmann, H., Baran, H., Kish, S.J., Seitelberger, F., and Hornykiewicz, 0., 1983, Kainic acid induced seizures: neurochemical and histopathological changes, Neuroscience, 10: 1301.
Stewart, W.W., 1978, Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer, Cell, 14: 744.
Turner, D.A., and Schwartzkroin, P.A., 1984, Passive electronic structure and dendritic properties of hippocampal neurons, in: Brain Slices,R. Dingledine, ed., Plenum Press, New York, p. 25.
Valdes, F., Dashieff, R.M., Birmingham, F., Crutcher, K., and McNamara,J.0., 1982, Benzodiazepine receptor increases following repeated seizures: evidence for localization to dentate granule cells, Proc. Natl. Acad.Sci. USA, 79:193.
Ward, A.A., Jr., 1978, Glia and epilepsy, in: Dynamic Properties of Glial Cells, F. Schoffeniels, G. Franck, L. Hertz, and D.B. Tower, eds., Pergamon Press, Oxford, p. 413.
Westrum, L.E., White, L.E., Jr., and Ward, A.A., Jr., 1964, Morphology of the experimental epileptic focus, J. Neurosurg21:1033.
Wheal, H.V., Ashwood, T., and Lancaster, B., 1984, A comparative in vitro study of the kainic acid lesioned and bicuculline treated hippocampus: chronic and acute models of focal epilepsy, in: Electrophysioloav of Epilepsy, P.A. Schwartzkroin and H.V. Wheal, eds., Academic Press, London, p. 173.
Woodbury, D.M., and Kemp, J.W., 1977, Basic mechanisms of seizures: neuro-physiological and biochemical etiology, in: Psychopathology and Brain Dysfunction, C. Shagass, S. Gershon, and A.J. Friedhof, eds., Raven Press, New York, p. 149.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Schwartzkroin, P.A., Franck, J.E. (1986). Electrophysiology of Epileptic Tissue: What Pathologies are Epileptogenic?. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7971-3_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7973-7
Online ISBN: 978-1-4684-7971-3
eBook Packages: Springer Book Archive