Abstract
The kindling model of epilepsy was discovered relatively recently (Goddard et al., 1969), yet it is already the most extensively studied animal model of epilepsy. Despite extensive study, the mechanisms responsible for kindling are unknown. Our intent in this chapter is: 1) to identify some difficulties confronting investigations of the mechanisms; 2) to describe our studies of the substantia nigra in kindling; and 3) to consider how these studies of the substantia nigra may contribute to understanding the mechanisms of kindling.
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References
Babington, R.G., and Wedeking, P.W., 1973, The pharmacology of seizures induced by sensitization with low intensity brain stimulation, Pharmacol. Biochem. Behay., 1:461.
Bonhaus, D.W., Walters, J.R., and McNamara, J.0., 1986, Activation of substantia nigra neurons: role in the propagation of seizures in kindled rats, J, Neurosci., in press.
Blackwood, D.H.R., Kapoor, V., and Martin, M.J., 1981, Regional changes in cerebral glucose utilization associated with amygdaloid kindling and electroshock in the rat, Brain Res., 224: 204.
Bunney, B.S., and Aghajanian, G.K., 1976, The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique, Brain Res., 117: 423.
Collins, R.C., Tearse, R.G., and Lothman, E.W., 1983, Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat, Brain Res., 280: 25.
Engel, J., Jr., Wolfson, L., and Brown, L., 1978, Anatomical correlates of electrical and behavioral events related to amygdaloid kindling, Ann. Neurol., 3:538.
Gale, K., 1985, Mechanisms of seizure control mediated by gamma aminobutyric acid: role of the substantia nigra, Fed. Proc., 44:2414.
Gerfen, C.R., Staines, W.A., Arbuthnott, G.W., and Fibiger, H.C., 1982, Crossed connections of the substantia nigra in the rat, J. Comp. Neurol., 207:283.
Goddard, G.V., McIntyre, D.C., and Leech, C.K., 1969, A permanent change in brain function resulting from daily electrical stimulation, Exp. Neurol., 25:295.
Hikosaka, 0., and Wurtz, R.H., 1985, Modification of saccadic eye movements by GABA-related substances. H. Effects of muscimol in monkey substantia nigra pars reticulata, J. Neurophvs., 53:292.
Iadarola, M.J., and Gale, K., 1982, Substantia nigra: site of anticonvulsant activity mediated by y-aminobutyric acid, Science, 218: 1237.
King, P.H., and McNamara, J.0., 1984, Microinjection of clonazepam into substantia nigra suppressed kindled seizures, Soc. Neurosci. Abstr., 10:343.
Le Gal La Salle, G., Kajima, M., and Feldblum, S., 1983, Abortive amygdaloid kindled seizures following microinjection of y-vinyl-GABA in the vicinity of substantia nigra in rats, Neurosci. Lett., 36:69.
Loughlin, S.E., and Fallon, J.H., 1983, Dopaminergic and non-dopaminergic projections to amygdala from substantia nigra and ventral tegmental area, Brain Res., 262: 334.
McNamara, J.0., Rigsbee, L.C., and Galloway, M.T., 1983, Evidence that substantia nigra is crucial to neural network of kindled seizures, Eur, J. Pharmacol., 86:485.
McNamara, J.0., Galloway, M.T., Rigsbee, L.C., and Shin, C., 1984, Evidence implicating substantia nigra in regulation of kindled seizure threshold, J. Neurosci., 4:2410.
McNamara, J.0., Bonhaus, D., Crain, B.J., Gellman, R.J., Giacchino, J.L., and Shin, C., 1985, The kindling model of epilepsy: a critical review, CRC Crit. Rev. Neurobiol., 1:341.
Myslobodsky, M.S., Ackerman, R.F., and Engel, J., 1979, Effects of y-acetylenic GABA and y-vinyl GABA on metrazol-activated and kindled seizures, Pharmacol. Biochem, Behay., 11:265.
Parent, A., Mackey, A., Smith, Y., and Boucher, R., 1983, The output organization of the substantia nigra in primate as revealed by a retrograde double labeling method, Brain Res. Bull., 10:529.
Racine, R.J., 1972, Modification of seizure activity by electrical stimulation. II. Motor seizure, Electroencephaloar. Clin. Neurophysiol., 32:281.
Shin, C., Silver, J.M., Bonhaus, D.W., and McNamara, J.O., 1985, The role of substantia nigra in the development of kindling, Soc. Neurosci. Abstr., 11:40.
Wada, J.A., and Sato, M., 1974, Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats: correlative electrographic and behavioral features, Neurology 24: 565.
Wada, J.A., Sato, M., and McCaughran, J.A., Jr., 1975, Cortical electrographic correlates of convulsive seizure development induced by daily electrical stimulation of the amygdala in rats and cats, Folia Psychiatr. Neurol. Japonica 29:329.
Wada, J.A., and Osawa, T., 1976, Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons (Papio papio) Neurology, 26: 273.
Waszczak, B.L., Eng, N., and Walters, J.R., 1980, Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons, Brain Res., 188: 185.
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© 1986 Plenum Press, New York
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McNamara, J.O., Bonhaus, D.W., Shin, C. (1986). Role of the Substantia Nigra in the Kindling Model of Limbic Epilepsy. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_10
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DOI: https://doi.org/10.1007/978-1-4684-7971-3_10
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