Skip to main content

What is the Normal Function of Genes which Give Rise to Homeotic Mutations?

  • Chapter
Development and Neurobiology of Drosophila

Part of the book series: Basic Life Sciences ((BLSC,volume 16))

Abstract

A homeotic mutation may be defined as one which causes a transformation of the determined state of some or all of the cells of a particular imaginal disc or disc compartment of the determined state characteristic of some other disc or disc compartment. Mutations such as these have been intriguing geneticists and developmental biologists for more than fifty years because they seem to offer insight into how genes control developmental processes. A fundamental question raised by their very existence concerns the nature of the normal functions of those genes which can give rise to such homeotic mutations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Balkaschina, E.I., 1929, Ein fall der erbohomöosis (die genovariation “aristapedia”) bei Drosophila melanogaster, Roux Archiv. Entwicklungsmech. Org., 115: 448.

    Article  Google Scholar 

  • Bridges, C.B., and Dobzhansky, T., 1933, The mutant proboscipedia in Drosophila melanogaster - a case of hereditary homeosis, Roux Archiv. Entwicklungsmech. Org., 127: 575.

    Article  Google Scholar 

  • Davis, K.T., and Shearn, A:, 1977, In vitro growth of imaginal disks from Drosophila melanogaster, Science, 196:438.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Bellido, A., 1977, Homeotic and atavic mutations in insects, Amer. Zool., 17: 613.

    Google Scholar 

  • Hadorn, E., 1963, Differenzirungsleistungen wiederholt fragmentierter teilstücke männlicher genitalscheiben von Drosophila melanogaster nach kultur in vivo, Devel. Biol., 7: 617.

    Article  Google Scholar 

  • Hadorn, E., 1978, Imaginal Discs: Transdetermination, in:“The Genetics and Biology of Drosophila, Vol. 2c”, M. Ashburner and T.R.F. Wright, eds., Academic Press, London.

    Google Scholar 

  • Herskowitz, I., 1949, Hexaptera, a homeotic mutant in Drosophila melanogaster, Genetics, 34: 10.

    PubMed  CAS  Google Scholar 

  • Kauffmann, S., 1973, Control circuits for determination and trans-determination, Science, 181: 310.

    Article  Google Scholar 

  • LeCalvez, J., 1948, In(3R)ssAr: Mutation aristapedia héterozygote dominant, homozygote léthale chez Drosophila melanogaster, Bull. Biol. France Belg., 82: 97.

    Google Scholar 

  • Lewis, E.B., 1964, Genetic control and regulation of pathways, in: “The Role of Chromosomes in Development”, M. Locke, ed., Academic Press, New York.

    Google Scholar 

  • Morata, G., and Lawrence, P.A., 1975, Control of compartment development by the engrailed gene in Drosophila, Nature, 255: 614.

    Article  PubMed  CAS  Google Scholar 

  • Ouweneel, W.J., 1976, Developmental genetics of homeosis, Adv. Genet., 18: 179.

    Article  PubMed  CAS  Google Scholar 

  • Shearn, A., 1974, Complementation analysis of late lethal mutants of Drosophila melanogaster, Genetics, 77: 115.

    PubMed  CAS  Google Scholar 

  • Shearn, A., 1978, Mutational dissection of imaginal disc development, in: “Genetics and Biology of Drosophila, Vol.2C”, M. Ashburner and T.R.F. Wright,, eds., Academic Press, London.

    Google Scholar 

  • Shearn, A., Davis, K.T., and Hersperger, E., 1978a, Transdetermination of Drosophila imaginal discs cultured in vitro, Devel. Biol., 65: 536.

    Article  CAS  Google Scholar 

  • Shearn, A., Hesperger, G., and Hersperger, E., 1978b, Genetic analysis of two allelic temperature-sensitive mutants of Drosophila melanogaster both of which are zygotic and maternal effect lethals, Genetics, 89: 341.

    PubMed  CAS  Google Scholar 

  • Shearn, A., Rice, T., Garen, A. and Gehring, W., 1971, Imaginal disc abnormalities in lethal mutants of Drosophila, Proc. Natl. Acad. Sci. U.S.A., 68: 2594.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer Science+Business Media New York

About this chapter

Cite this chapter

Shearn, A. (1980). What is the Normal Function of Genes which Give Rise to Homeotic Mutations?. In: Siddiqi, O., Babu, P., Hall, L.M., Hall, J.C. (eds) Development and Neurobiology of Drosophila . Basic Life Sciences, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7968-3_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7968-3_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7970-6

  • Online ISBN: 978-1-4684-7968-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics