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Prostanoids and Drugs pp 55–64Cite as

Leukotrienes in the Lung and Cardiovascular System

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Part of the book series: NATO ASI Series ((NSSA,volume 177))

Abstract

The formation of leukotrienes (LTs) from arachidonic acid derived from phospholipids of the cell membrane is initially catalysed by 5-lipoxygenasel. Metabolism of the unstable epoxide LTA4 leads to the formation of LTB4 and the cysteinyl-containing LTs C4, D4 and E4. All these LTs have potent, although different, biological activities. LTB4 is a powerful chemotactic agent for leukocytes whereas LTs C4, D4 and E4 have potent smooth muscle stimulating actions and account for the biological activity of the allergic mediator previously known as slow-reacting substance of anaphylaxis (SRS-A)2. Leukotriene B4 has pro-inflammatory actions but little smooth muscle stimulating activity of its own whereas cysteinyl-containing LTs have potent actions in the cardiovascular system and in the airways in vitro and in vivo (see3,4).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons of England, London, WC2A 3PN, UK

    Priscilla J. Piper, Marwa N. Samhoun, Dolores M. Conroy & H. B. Yaacob

  2. Department of Thoracic Medicine, Kings College School of Medicine and Dentistry, London SE5, UK

    N. C. Barnes, Jane M. Evans & J. F. Costello

Authors
  1. Priscilla J. Piper
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  2. Marwa N. Samhoun
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  3. Dolores M. Conroy
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  4. H. B. Yaacob
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  5. N. C. Barnes
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  6. Jane M. Evans
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  7. J. F. Costello
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Editor information

Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti

  3. University of Parma, Parma, Italy

    G. C. Folco

  4. University of Verona, Verona, Italy

    G. P. Velo

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© 1989 Plenum Press, New York

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Piper, P.J. et al. (1989). Leukotrienes in the Lung and Cardiovascular System. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Prostanoids and Drugs. NATO ASI Series, vol 177. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7938-6_8

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  • DOI: https://doi.org/10.1007/978-1-4684-7938-6_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7940-9

  • Online ISBN: 978-1-4684-7938-6

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