Abstract
Lipoxygenase products of arachidonic acid are important lipid mediators in inflammatory responses, immunity, and other physiological and pathophysiological processes (1). Recently, a new class of conjugated trihyroxytetraenes derived from oxygenation of arachidonic acid (AA) and eicosapentatenoic acid (EPA) via interactions between the 5- and 15 lipoxygenase pathways have been reported by Serhan et al. (2) and Wong et al. (3). This novel group of compounds are denoted as “Lipoxin” (LX) A4/B4 and A5/B5, respectively.
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References
B.Samuelsson, S.E. Dahlen, J. Lindren, C.A. Rouzer, and C.N. Serhan, Leukotrienes and lipoxins: structure, biosynthesis, and biological effects, Science 237: 1171 (1987).
C.N. Serhan, M. Hamberg, and B. Samuelsson, Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes, Proc. Natl. Acad. Sci USA. 81: 5335 (1984).
P.Y-W Wong, R. Hughes, and B. Lam, Lipoxene: a new group of trihydroxy pentaenens of eicosapentaenoic acid derived from porcine leukocytes, Biochem. Biophys. Res. Commun. 126: 763 (1985).
C.N. Serhan, and B. Samuelsson, Lipoxins: a new series of eicosanoids (biosynthesis, stereochemistry and biological activities), in "Lipoxins Biosynthesis, Chemistry and Biological Activities", P.Y-K Wong and C.N. Serhan, ed., Plenum Press, New York (1988).
C.F. Ng, B.K. Lam, K. Pritchard, M. Stemerman, and P.Y-K Wong, Formation of lipoxins by rat basophilic leukemic cells, Fed. Proc. 5: 5634 (1988).
N. Ueda, C. Yokoyama, S. Yamamoto, B.J. Fitzsimmons, J. Rokach, J. Oates, and A.R. Brash, Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leuokcytes, Biochem. Biophys. Res. Commun. 149: 1063 (1987).
A. Hansson, C.N. Serhan, J. Haeggstrom, M. Ingelman-Sundberg, and B. Samuelsson, Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation produces arachidonic acid, Biochem Biophys Res. Commun 134: 1215 (1986).
S.E. Dahlen, J. Raud, C.N. Serhan, J. Bjork, and B. Samuelsson, Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo, Acta Physiol Scand. 130: 643 (1987).
U. Ramstedt, J. Ng, H. Wigzell, C.N. Serhan, and B. Samuelsson, Action of novel eicosanoids. Lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding, J. Immunol. 135: 3434 (1985).
T. Galliard, and J.A. Matthew, Enzymic reactions of fatty acid hydroperoxides in extracts of potato tuber, Bio. Biophys. Acta. 398: 1 (1975).
C.N. Serhan, M. Hamberg, B. Samuelsson, J. Morris, and D.G. Wishka, On the stereochemistry and biosynthesis of lipoxin B, Proc. Natl. Acad. Sci. USA, 83: 1983 (1986).
S.E. Dahlen, L. Franzen, J. Raud, C.N. Serhan, P. Westlund, E. Wikstrom, T. Bjorck, H. Matsuda, SE. Webber, C.A. Veale, T. Puustinen, J. Haeggstrom, K.C. Nicolaou, and B. Samuelsson, Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo, in "Lipoxins Biosynthesis Chemistry and Biological Activities", P.Y-K Wong, and C.N. Serhan, ed., Plenum Press, New York (1988).
W.S. Powell, and F. Gravelle, Metabolism of 6-trans isomers of leukotriene B4 to dihydro products by human polymorphonuclear leukocytes, J. Biol. Chem. 263: 2170 (1987).
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© 1989 Plenum Press, New York
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Ng, C.F., Ho, HY., Wong, P.YK. (1989). Lipoxins: Biosynthesis, Metabolism and Physiological Functions. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Prostanoids and Drugs. NATO ASI Series, vol 177. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7938-6_7
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DOI: https://doi.org/10.1007/978-1-4684-7938-6_7
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