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Prostanoids and Drugs pp 137–144Cite as

Role of Leukotrienes in Experimental Gastric Ulceration

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Part of the book series: NATO ASI Series ((NSSA,volume 177))

Abstract

Gastric mucosal damage induced by topical irritants such as ethanol, strong acid or strong base are preceded by severe disturbances of the gastric mucosal microcirculation resulting in a decrease in mucosal blood flow, vascular stasis, marked engorgement of microvessels and leakage of plasma proteins and blood cells.1,2 Gastroprotective compounds such as prostaglandins (PG) prevent the microcirculatory changes caused by the irritants.1.2 The cysteinyl leukotrienes (LT) LTC4 and LTD4 infused into the arterial supply of the rat stomach cause a rapid and marked decrease in vascular flow rate.3,4 Furthermore, LTC4, but not LTD4, has been found to induce sluggish blood flow and stasis in the rat gastric submucosal microcirculation closely resembling the effects of topical irritants.5 Finally, both LTC4and LTD4, although not ulcerogenic themselves, potentiate the noxious effects of gastric irritants.6,7

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Author information

Authors and Affiliations

  1. Department of Experimental Clinical Medicine, Ruhr-University of Bochum, Bochum, Germany

    B. M. Peskar, E. Bacha & P. Nowak

Authors
  1. B. M. Peskar
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  2. E. Bacha
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  3. P. Nowak
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Editor information

Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti

  3. University of Parma, Parma, Italy

    G. C. Folco

  4. University of Verona, Verona, Italy

    G. P. Velo

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© 1989 Plenum Press, New York

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Peskar, B.M., Bacha, E., Nowak, P. (1989). Role of Leukotrienes in Experimental Gastric Ulceration. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Prostanoids and Drugs. NATO ASI Series, vol 177. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7938-6_15

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  • DOI: https://doi.org/10.1007/978-1-4684-7938-6_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7940-9

  • Online ISBN: 978-1-4684-7938-6

  • eBook Packages: Springer Book Archive

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