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Prostaglandin Oligomers: Potential Agents for the Protection Against The Effects of Oxygen Deprivation

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Biotechnological Applications of Lipid Microstructures

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 238))

Abstract

Prostaglandin derived oligomers are mixtures derived from the prostaglandin B1 (PGB1) family having the general formula (PGB1)n. In recent years, these materials have been derived exclusively from 15-dehydro-prosta-glandin B1 (15-dehydro-PGB1, 1a) and its derivatives. A number of unique in vitro and in vivo properties have been reported for these mixtures which appear to indicate an ability to prevent or restore damage at the cellular level resulting from oxygen deprivation. These properties suggest a potential application as a pharmaceutical agent or agents for protection against the harmful effects of stress, such as hypoxia and shock. The general lack of structural characterization of the initial mixtures has resulted in a serious block to the further development of these materials. Recently, structurally-defined dimer and trimer components, derived from a structurally modified 15-dehydro-PGB1 under mild reaction conditions, have been prepared. These structurally less complicated dimers and trimers retain the unique in vitro activities exhibited by the complex and structurally-undefined mixtures originally reported.

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Authors and Affiliations

  1. Department of Chemistry, Saint Joseph’s University, Philadelphia, PA, 19131, USA

    George L. Nelson

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  1. George L. Nelson
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Editors and Affiliations

  1. Naval Research Laboratory, Washington, D.C., USA

    Bruce Paul Gaber  & Joel M. Schnur  & 

  2. Royal Free Hospital School of Medicine, London, UK

    Dennis Chapman

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© 1988 Plenum Press, New York

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Nelson, G.L. (1988). Prostaglandin Oligomers: Potential Agents for the Protection Against The Effects of Oxygen Deprivation. In: Gaber, B.P., Schnur, J.M., Chapman, D. (eds) Biotechnological Applications of Lipid Microstructures. Advances in Experimental Medicine and Biology, vol 238. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7908-9_28

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  • DOI: https://doi.org/10.1007/978-1-4684-7908-9_28

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7910-2

  • Online ISBN: 978-1-4684-7908-9

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