Biomembranes: Structure of Biomembranes and Their Models

  • Dennis Chapman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 238)


There has now been considerable basic research devoted to an understanding of Biomembrane Structure and Function. This research has revealed the general structure of biomembranes such as the importance of the lipid bilayer matrix, the various arrangements of the proteins which are extrinsic in some cases and intrinsic or integral in others. Detailed studies by a variety of physical techniques have given information about the dynamic characteristics of biomembranes including properties such as fluidity, phase transitions, diffusion characteristics and in a very few cases detailed information about integral protein structure. In this talk I will attempt to summarise some of these studies so as to provide a basis for the development of our later discussions on the technological possibilities of membrane mimicry for vesicles, thin films, biosensors, etc.


Lipid Bilayer Sarcoplasmic Reticulum Rotational Diffusion Integral Protein Purple Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Amey, R.L. and Chapman, D. (1983) in “Biomembrane Structure and Function”, D. Chapman, ed., pp. 199–256, Macmillan, London.Google Scholar
  2. Asher, J.M. and Levin, I.W. (1977) Biochim. Biophys. Acta 468:63.Google Scholar
  3. Blaurock, A.E. and Wilkins, M.F.H. (1969) Nature (London) 223:906.CrossRefGoogle Scholar
  4. Bretscher, M. (1973) Science 181:622.CrossRefGoogle Scholar
  5. Cameron, D.G., Casal, H.L. and Mantsch, H.H. (1980) Biochemistry 19:3665.CrossRefGoogle Scholar
  6. Chapman, D. and Penket, S.A. (1966) Nature (London) 211:1304.CrossRefGoogle Scholar
  7. Chapman, D. and Urbina, J. (1971) FEBS Lett. 12:169.CrossRefGoogle Scholar
  8. Chapman, D., Owen, N., Phillips, M. and Walker, D. (1969) Biochim. Biophys. Acta 183:458.CrossRefGoogle Scholar
  9. Chapman, D., Gomez-Fernandez, J. and Goni, F. (1979) FEBS Lett 98:211.CrossRefGoogle Scholar
  10. Cherry, R.J., Burkli, A., Busslinger, M., Schneider, G. and Parish, G.R. (1976) Nature (London) 263:389.CrossRefGoogle Scholar
  11. Cone, R. (1972) Nature (London) 236:39.Google Scholar
  12. Cortijo, M. and Chapman, D. (1981) FEBS Lett. 131:245.CrossRefGoogle Scholar
  13. Cortijo, M., Alonso, A., Gomez-Fernandez, J. and Chapman, D. (1982) J. Mol. Biol. 157:597.CrossRefGoogle Scholar
  14. Cullis, P.R. and de Kruijff, B. (1978) Biochim. Biophys. Acta 513:31.CrossRefGoogle Scholar
  15. Cullis, P.R. and de Kruijff, B. (1979) Biochim. Biophys. Acta 559:39.CrossRefGoogle Scholar
  16. Dluhy, R.A., Mendelsohn, R., Casal, H. L. and Mantsch, H. H. (1983) Biochemistry 22:1170.CrossRefGoogle Scholar
  17. Durrani, A.A., Hayward, J.A. and Chapman, D. (1986) Biomaterials 7:121.CrossRefGoogle Scholar
  18. Dux, L. and Martonosi, A. (1983a) J. Biol. Chem. 258:10111.PubMedGoogle Scholar
  19. Dux, L. and Martonosi, A. (1983b) J. Bio. Chem. 258:11896.Google Scholar
  20. Fringeli, U.P. and Gunthard, H.H. (1981) Mol. Biol. Biochem. Biophys. 31:270.CrossRefGoogle Scholar
  21. Garavito, R.M., Jenkins, J., Jansonius, J.N., Karlsson, R. and Rosenbusch, J.P. (1983) J. Mol. Biol. 164:313.CrossRefGoogle Scholar
  22. Gennis, R. and Jonas, A. (1977) Annu. Rev. Biophys. Bioeng. 6:195.CrossRefGoogle Scholar
  23. Hayward, J.A., Levine, D.M., Neufeld, L., Simon, S.R., Johnston, D.S. and Chapman, D. (1985) FEBS Lett. 187:261.CrossRefGoogle Scholar
  24. Henderson, R. and Unwin, P. (1975) Nature (London) 257:28.CrossRefGoogle Scholar
  25. Hoffman, W. and Restall, C. (1983) in “Biomembrane Structure and Function”, D. Chapman, ed., pp. 257–318, Macmillan, London.CrossRefGoogle Scholar
  26. Hoffman, W., Sarzala, M. and Chapman, D. (1979) Proc. Natl. Acad. Sci., U.S.A. 76:3860.CrossRefGoogle Scholar
  27. Jackson, M.B. and Sturtevant, J.M. (1978) Biochemistry 17:911.CrossRefGoogle Scholar
  28. Johnston, D.S., Sanghera, S., Pons, M. and Chapman, D. (1980) Biochim. Biophys. Acta 602:57.CrossRefGoogle Scholar
  29. Johnston, D.S., McLean, L.R., Whittam, M.A., Clark, A.D. and Chapman, D. (1983) Biochemistry 22:3192.Google Scholar
  30. Jost, P., Griffith, O., Capaldi, R. and Vanderkooi, G. (1973) Proc. Natl. Acad. Sci., U.S.A. 70:480.CrossRefGoogle Scholar
  31. Leaver, J., Alonso, A., Durrani, A.A. and Chapman, D. (1983) Biochim. Biophys. Acta 727:327.CrossRefGoogle Scholar
  32. Lee, D.C. and Chapman, D. (1986) Biosci. Rpt. 6:235.CrossRefGoogle Scholar
  33. Lee, D.C., Durrani, A.A. and Chapman, D. (1984) Biochim. Biophys. Acta 769:49.Google Scholar
  34. Lee, D.C., Hayward, J.A., Restall, C.J. and Chapman, D. (1985) Biochemistry 24:4364.CrossRefGoogle Scholar
  35. Luzzati, V. and Husson, F. (1972) J. Cell. Biol. 12:207.CrossRefGoogle Scholar
  36. Michel, H. (1982) J. Mol. Biol. 158:567.CrossRefGoogle Scholar
  37. Murray, E., Restall, C. and Chapman, D. (1983) Biochim. Biophys. Acta 732:347.CrossRefGoogle Scholar
  38. Naqvi, K., Gonzalez-Rodriguez, J., Cherry, R. and Chapman, D. (1973) Nature (London) 245:249.CrossRefGoogle Scholar
  39. Nicolson, G.L. (1976) Biochim. Biophys. Acta 457:57.CrossRefGoogle Scholar
  40. Oldfield, E. and Chapman, D. (1972) FEBS Lett. 23:285.CrossRefGoogle Scholar
  41. Oldfield, E., Chapman, D. and Derbyshire, W. (1971) FEBS Lett. 16:102.CrossRefGoogle Scholar
  42. Oldfield, E., Chapman, D. and Derbyshire, W. (1972) Chem. Phys. Lipids 9:69.CrossRefGoogle Scholar
  43. Oldfield, E., Gilmore, R., Gloser, M., Gutowshy, H., Hsung, J., Kang, S., King, T., Meadows, M. and Rice, D. (1978) Proc. Natl. Acad. Sci., U.S.A. 75:4657.CrossRefGoogle Scholar
  44. Op den Kamp, J. (1979) Annu. Rev. Biochem. 48:47.CrossRefGoogle Scholar
  45. Paddy, M., Dahlquist, F., Davis, J. and Bloom, M. (1981) Biochemistry 20:3152.CrossRefGoogle Scholar
  46. Restall, C., Murray, E., Dale, W. and Chapman, D. (1985a) Biochemistry 23:6765.CrossRefGoogle Scholar
  47. Restall, C., Coke, M., Murray, E. and Chapman, D. (1985b) Biochim. Biophys. Acta 813:96.CrossRefGoogle Scholar
  48. Rice, D., Meadows, M., Scheinmann, A., Goni, F., Gomez-Fernandez, J., Moscarello, M., Chapman, D and Oldfield, E. (1979) Biochemistry 18:5893.PubMedGoogle Scholar
  49. Rothman, J. and Lenard, J. (1977) Science 195:743.CrossRefGoogle Scholar
  50. Singer, S.J. and Nicolson, G.L. (1972) Science 175:720.CrossRefGoogle Scholar
  51. Steim, J., Tourtelotte, M., Reinert, J., McElhaney, R. and Rader, R. (1969) Proc. Natl. Acad. Sci., U.S.A. 63:104.CrossRefGoogle Scholar
  52. Taylor, M.G. and Smith, I.C.P (1980) Biochim. Biophys. Acta 599:140.CrossRefGoogle Scholar
  53. Unwin, P. and Henderson, R. (1975) J. Mol. Biol. 94:425CrossRefGoogle Scholar
  54. Weite, W. and Kreutz, W. (1982) Biochim. Biophys. Acta 692:479.CrossRefGoogle Scholar
  55. Weite, W., Hodapp, N., Aehnelt, C. and Kreutz, W. (1981) Biophys. Struct. Mech. 7:209.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Dennis Chapman
    • 1
  1. 1.Department of Biochemistry and ChemistryRoyal Free Hospital School of MedicineLondonUK

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