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Compliance and Aging

  • Chapter
Vascular Dynamics

Part of the book series: NATO ASI Series ((ASIAS,volume 166))

Abstract

It is well-documented that arterial stiffness increases with age (Roy, 1880; Hallock and Benson, 1937; Hass, 1942; Butcher and Newton, 1958; Roach and Burton, 1959; Learoyd and Taylor, 1966; Bader, 1967; Nakashima and Tanikawa, 1971; Mozersky et al., 1973; Gozna et al., 1974; Mirsky and Janz, 1976; Cox, 1977; Newman and Lallemand, 1978; Langewouters, 1982; Yin, Spurgeon and Kallman, 1983). Richter and Mittermayer (1984) reported that the volume of the postmortem human aorta is 35 ml at age 20 years, while at 70 years the volume increases to an average of 111 ml. With age the vessel becomes dilated and stiffens (Learoyd and Taylor, 1966; Nichols et al., 1985). There seems to be little doubt that arteriosclerosis, a frequent complicating aspect of the aging process in modern life, results in severe stiffening of the thoracic aorta, as well as other, more peripheral, vessels. The role that atherosclerosis plays in arterial stiffening has not been well defined.

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References

  • Apter, J.T., Rabinowitz, M. and Cummings, D.H., 1966, Correlation of viscoelastic properties of large arteries with microscopic structure. I. Collagen, elastin and muscle determined chemically, histologically, and physiologically, Circ. Res., 19: 104.

    Article  CAS  Google Scholar 

  • Avolio, A.P., Chen, S., Wang, R., Zhang, C., Li, M. and O’Rourke, M.F., 1983, Effects of aging on changing arterial compliance and left ventricular load in a northern chinese urban community, Circulation, 68: 50.

    Article  PubMed  CAS  Google Scholar 

  • Avolio, A.P., Deng, F.D., Li, W., Lou, Y., Huang, Z., Xing, L. and O’Rourke, M.F., 1984, Effects of aging on arterial distensibility in populations with high and low prevelance of hypertension: comparison between urban and rural communities in China. Circulation, 71: 207.

    Google Scholar 

  • Baan, J., van der Velde, E.T., de Bruin, H.G. and Karsdon, J., 1987, Control of the end-systolic pressure-volume relation, in: “Simulation and control of the cardiac system,”: S. Sideman and R. Beyar, eds., CRC press, Boca Raton, Fl., pp 163.

    Google Scholar 

  • Bader, H., 1967, Dependence of wall stress in human thoracic aorta on age and pressure, Circ. Res., 20: 354.

    Article  PubMed  CAS  Google Scholar 

  • Bramwell, J.C. and Hill, A.V., 1922, The velocity of the pulse wave in man, Proc. Roy. Soc. Lond (Biol.), 93: 298.

    Article  Google Scholar 

  • Bramwell, J.C., Hill, A.V. and McSwiney, B.A., 1923, The velocity of the pulse wave in man in relation to age as studied by the hot-wire sphygmograph, Heart, 10: 233.

    Google Scholar 

  • Butcher, H.B. and Newton, W.T., 1958, The influence of age, arteriosclerosis and homotransplantation upon the elastic properties of major human arteries, Ann. Surg., 148: 1.

    Article  PubMed  Google Scholar 

  • Cleary, E., 1963, “A correlative and comparative study of the nonuniform arterial wall,” M.D. Thesis, University of Sidney.

    Google Scholar 

  • Cotton, R. and Wartman, W.B., 1961, Endothelial patterns, in human arteries, their relationship to age, vessel site, and atherosclerosis, Arch. Pathol., 2: 15.

    Google Scholar 

  • Cox, R.H., 1977, Effects of age on the mechanical properties of rat carotid artery, Am. J. Physiol., 233: H256.

    PubMed  CAS  Google Scholar 

  • Eliakim, M., Sapozinikov, D. and Weinman, J., 1971, Pulse wave velocity in healthy subjects and in patients with various disease states. Am. Heart J., 82: 448.

    Article  PubMed  CAS  Google Scholar 

  • Faber, M. and Moller-Hou, G., 1952, The human aorta. V. Collagen and elastin in the normal and hypertensive aorta, Acta Pathol. Microbiol. Scand., 31: 377.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, G.M. and Llaurado, J.G., 1966, Collagen and elastin content in canine arteries selected from functionally different vascular beds, Circ. Res., 19: 394.

    Article  PubMed  CAS  Google Scholar 

  • Freis, E.D., Heath, W.C., Luchsinger, P.C. and Snell, R.E., 1967, Changes in the carotid pulse which occur with age and hypertension, Am. Heart J., 71: 757.

    Article  Google Scholar 

  • Gentile, B.J., Gross, D.R., Chuong, C.J.C. and Hwang, N.H.C., 1988, Segmental volume distensibility of the canine thoracic aorta, in vivo, Cardiovasc. Res., 22: 385.

    Article  PubMed  CAS  Google Scholar 

  • Gozna, E.R., Marble, A.E., Shaw, A. and Holland, J.G., 1974, Age-related changes in the mechanics of the aorta and pulmonary artery of man, J. Appl. Physiol., 36: 407.

    PubMed  CAS  Google Scholar 

  • Gray, R.J., Handler, F.P., Blanche, J.O., Zuckner, J. and Blumenthal, H.T., 1953, Aging process of aorta and pulmonary artery in negro and white races, Arch. Pathol., 56: 238.

    CAS  Google Scholar 

  • Guard, H.R. and Bhende, J.M., 1953, Changes due to aging in the abdominal aorta, Ind. J. Med. Res., 41: 267.

    CAS  Google Scholar 

  • Hallock, P., 1934, Arterial elasticity in man in relation to age as evaluated by the pulse wave velocity method, Arch. Intern. Med., 54: 770.

    Article  Google Scholar 

  • Hallock, P. and Benson, I.C., 1937, Studies on the elastic properties of human isolated aorta, J. Clin. Invest., 16: 595.

    Article  PubMed  CAS  Google Scholar 

  • Harkness, M.L.R., Harkness, R.D. and McDonald, D.A., 1957, The collagen and elastin of the arterial wall in the dog, Proc. Roy. Soc. Biol., 146: 541.

    Article  PubMed  CAS  Google Scholar 

  • Hass, G.M., 1942, Elastic tissue, H. A study of the elasticity and tensile strength of elastic tissue isolated from the human aorta. Arch. Pathol., 34: 971.

    Google Scholar 

  • Landowne, M., 1958, The relation between intra-arterial pressure and impact pulse wavevelocity with regard to age and arteriosclerosis, J. Gerontol., 13: 153.

    Article  PubMed  CAS  Google Scholar 

  • Langewouters, G.J., 1982, “Visco-elasticity of the human aorta in vitro in relation to

    Google Scholar 

  • pressure and age,“ Ph.D. Thesis, Vrije Universiteit, Amsterdam, the Netherlands.

    Google Scholar 

  • Latham, R.D., 1988, Pulse propagation in the systemic arterial tree, in: “Vascular Dynamics”, N. Westerhof and D. R. Gross, eds., Plenum Press, New York, N. Y.

    Google Scholar 

  • Leoroyd, B. and Taylor, M.G., 1966, Alterations with age in the viscoelastic properties of human arterial walls, Circ. Res., 18: 278.

    Article  Google Scholar 

  • Milch, R.A., 1965, Matrix properties of the aging arterial wall, Mono. Surg. Sci., 2:261. Mirsky, I. and Janz, R.F., 1976, The effect of age on wall stiffness and human thoracic aorta: A large deformation “anisotropic” analysis, J. Theor. Biol., 59: 467.

    Google Scholar 

  • Moritz, A.R. and Oldt, M.R., 1937, Arteriolar sclerosis in hypertension and nonhypertensives, Am. J. Pathol., 13: 679.

    PubMed  CAS  Google Scholar 

  • Mozersky, D.J., Sumner, D.S., Hokanson, D.E. and Strandness, D.E., 1973, Transcutaneous measurement of arterial wall properties as a potential method of estimating age, J. Am. Geriatr. Soc., 21: 18.

    PubMed  CAS  Google Scholar 

  • Murgo, J.P., Westerhof, N., Giolma, J.P. and Altobelli, S.A., 1980, Aortic input impedance in normal man: relationship to pressure wave slope, Circulation, 62: 105.

    Article  PubMed  CAS  Google Scholar 

  • Murgo, J.P., Westerhof, N., Giolma, J.P. and Altobelli, S.A., 1981(a), Manipulation of ascending aortic pressure and flow reflections with the Valsalva maneuver: relationship to input impedance, Circulation, 63: 122.

    Google Scholar 

  • Murgo, J.P., Westerhof, N., Giolma, I.P. and Altobelli, S.A., 1981(b), Effects of exercise on aortic input impedance and pressure wave forms in normal humans, Circ. Res., 48: 334.

    Google Scholar 

  • Myers, V.C. and Lang, W.W., 1946, Some chemical changes in the human thoracic aorta accompanying the aging process, J. Gerontol., 1: 441.

    Article  PubMed  CAS  Google Scholar 

  • Nakashima, T. and Tanikawa, J., 1971, A study of human aortic distensibility with relation to atherosclerosis and aging, Angiology, 22: 477.

    Article  PubMed  CAS  Google Scholar 

  • Newman, D.L. and Lallemand, R.c., 1978, The effect of age on the distensibility of the abdominal aorta of man, Surg. Gyn. Obst., 147: 211.

    PubMed  CAS  Google Scholar 

  • Nichols, W.W. and McDonald, D.A., 1972, Wave velocity in the proximal aorta, Med. Biol. Eng. Comp., 10: 327.

    Article  CAS  Google Scholar 

  • Nichols, W.W., O’Rourke, M.F., Avolio, A.P., Yaginuma, T., Murgo, J.P., Pepine, C.J. and Conti, C.R., 1985, Effects of age on ventricular-vascular coupling, Am. J. Cardiol., 55: 1179.

    Article  PubMed  CAS  Google Scholar 

  • Nichols, W.W., O’Rourke, M.f., Avolio, A.P., Yaginuma, T., Murgo, J.P., Pepine, C.J. and Conti, C.R., 1987, Age-related changes in left ventricular/arterial coupling, in: “Ventricular/Vascular Coupling,” F.C.P. Yin, ed., Springer-Verlag, New York.

    Google Scholar 

  • Nielson, B.L., Nielsen, J.S. and Fabricius, J., 1968, Pulse wave velocity in the human aorta, J. Am. Geriatr. Soc., 16: 647.

    Google Scholar 

  • O’Rourke, M.F., Avolio, A.P. and Nichols, W.W., 1987, Left ventricular-systemic arterial coupling in humans and strategies to improve coupling in disease states, in: “Ventricular/Vascular Coupling,” F.C.P. Yin, ed., Springer-Verlag, New York.

    Google Scholar 

  • O’Rourke, M.F., Blazek, J.V., Morreels, C.L. and Kronetz, L.T., 1968, Pressure wave transmission along the human aorta: changes with age and in arterial degenerative disease, Circ. Res., 23: 567.

    Article  PubMed  Google Scholar 

  • O’Rourke, M.F. and Taylor, M.G., 1966, Vascular impedance of the femoral bed, Circ. Res., 18: 126.

    Article  Google Scholar 

  • Pagani, M., Baig, H., Sherman, A., Manders, W.T., Quinn, P., Patrick, T., Franklin, D. and Vatner, S.F., 1978, Measurement of multiple simulatneous small dimensions and study of arterial pressure-dimension relations in conscious animals, Am. J. Physiol., 235: H610.

    PubMed  CAS  Google Scholar 

  • Patel, D.J., Coleman, B.R., Tearney, R.J., Cothran, L.N., and Curry, C.L., 1988, Peripheral vascular compliance, in: “Vascular Dynamics”, N. Westerhof and D. R. Gross, eds., Plenum Press, New York, N.Y.

    Google Scholar 

  • Patel, D.J. Mallos, A.J. and Fry, D.L., 1961, Aortic mechanics in the living dog. J. Appl. Physiol., 16: 293.

    CAS  Google Scholar 

  • Patel, D.J. and Fry, D.L., 1964, In situ pressure-radius-length measurements in ascending aorta of anesthetized dogs, J. Appl. Physiol., 19: 413.

    CAS  Google Scholar 

  • Patel, D.J. and Vaishnav, R.N., 1977, Mechanical properties of arteries, in: “Cardiovascular flow dynamics and measurements,” N.H.C. Hwang and N.R. Norman, eds., University Park Press, Baltimore.

    Google Scholar 

  • Puls, R.J. and Heizer, R.W., 1967, Pulse wave changing with aging, J. Am. Geriatr. Soc., 15: 153.

    PubMed  CAS  Google Scholar 

  • Richter, H.A. and Mittermayer, C.H., 1984, Volume elasticity, modulus of elasticity and compliance of normal and arteriosclerotic human aorta, Biorheology, 21: 723.

    PubMed  CAS  Google Scholar 

  • Roach, M.R. and Burton, A.C., 1959, The effect of age on the elasticity of human iliac arteries, Can. J. Biochem. Physiol., 37: 557.

    Article  PubMed  CAS  Google Scholar 

  • Roy, C.S., 1880, The elastic properties of the arterial wall, J. Physiol. (Lond.), 3:125. Schimmler, W. 1966, Correlation between the pulse wave velocity in the aortic iliac vessel and age, sex and blood pressure, Angiology, 17: 314.

    Google Scholar 

  • Simonson, E. and Nakagawa, K., 1960, Effect of age on pulse wave velocity and aortic ejection time in healthy men and in men with coronary artery disease, Circulation, 22: 126.

    Article  PubMed  CAS  Google Scholar 

  • Stehbens, W.E., 1979, “Hemodynamics and the Blood Vessel Wall,” Thomas, Springfield, IL.

    Google Scholar 

  • Suga, H., Goto, Y., Nozawa, T., Yasumura, Y., Futaki, S. and Tanaka, N., 1987, Force-time integral decreases with ejection despite constant oxygen consumption and pressure-volume area in dog left ventricle, Circ. Res., 60: 797.

    Article  PubMed  CAS  Google Scholar 

  • Suga, H. and Sagawa, K., 1974, Instantaneous pressure-volume relationship and their ratio in the excised, supported canine left ventricle, Circ. Res., 35: 117.

    Article  PubMed  CAS  Google Scholar 

  • Toorop, P.G., Westerhof, N. and Elzinga, G., 1987, Beat-to-beat estimation of peripheral resistance and arterial compliance during pressure transients, Am. J. Physiol., 252(21):HI275.

    Google Scholar 

  • van den Horn, G.J., Westerhof, N. and Elizinga, G., 1985, Optimal power generation by the left ventricle, Circ. Res., 56: 252.

    Article  PubMed  Google Scholar 

  • Yin, F.C.P., 1987, Aging and Vascular impedance, in: “Ventricular/Vascular Coupling,” F.C.P. Yin, ed., Springer-Verlag, New York.

    Chapter  Google Scholar 

  • Yin, F.C.P., Spurgeon, H.A. and Kallman, C.H., 1983, Age-associated alterations in viscoelastic properties of canine aortic strips, Circ. Res., 53: 464.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Physiology and Applied Physics Laboratory Department Veterinary Physiology and Pharmacology College of Veterinary Medicine, Texas A&M University, College Station, TX, USA

    David R. Gross

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  1. David R. Gross
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Editors and Affiliations

  1. Free University of Amsterdam, Amsterdam, The Netherlands

    N. Westerhof

  2. Texas A&M University, College Station, Texas, USA

    D. R. Gross

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© 1989 Plenum Press, New York

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Gross, D.R. (1989). Compliance and Aging. In: Westerhof, N., Gross, D.R. (eds) Vascular Dynamics. NATO ASI Series, vol 166. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7856-3_4

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  • DOI: https://doi.org/10.1007/978-1-4684-7856-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7858-7

  • Online ISBN: 978-1-4684-7856-3

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