Abstract
Although a clear distinction between the Werner syndrome and premature aging was made in our review published in 1966, repeated allusions in the literature indicate either an ambivalence about this relationship or a belief that the two conditions are fundamentally related to one another. Therefore, the criteria for premature aging originally used have been reexamined and found to be still acceptable. Evaluation of the features of the Werner syndrome in the light of these criteria once again indicates that there is no substantial evidence to support and considerable evidence to oppose equating the Werner syndrome with aging. This conclusion applies not only to the Werner syndrome in toto, but also to those aspects of the syndrome considered to qualify it as a segmental progeroid syndrome and to its characteristic cellular abnormalities (severely limited in vitro proliferation and variegated translocation mosaicism). The Werner syndrome should not, therefore, be forced into the mold of premature aging but should be studied on its own merits as a condition which may provide us with clues to the pathogenesis of many important problems.
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References
Casarett, G.W., 1964, Similarities and contrasts between radiation and time pathology. Advan. Gerontol. Res., 1: 109–163.
Comfort, A., 1959, Natural ageing and the effects of radiation. Radiat. Res. (Suppl.), 1: 216–234.
Comfort, A., 1979, “The Biology of Senescence,” 3rd ed., Elsevier, New York.
Epstein, C.J., Martin, G.M., and Motulsky, A.G., 1965, Werner’s syndrome: Caricature of aging, a genetic model for the study of degenerative diseases. Trans. Assoc. Amer. Phys., 78: 73–81.
Epstein, C.J., Martin, G.M., Schultz, A.L. and Motulsky, A.G., 1966, Werner’s syndrome. A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine, 45: 177–221.
Fujiwara, Y., Higashikawa, T., and Tatsumi, M., 1977, A retarded rate of DNA replication and normal level of DNA repair in Werner’s syndrome fibroblasts in culture. J. Cell. Physiol., 92: 365–374.
Goldstein, S., 1978, Human genetic disorders that feature premature onset and accelerated progression of biological aging, In “The Genetics of Aging”, E. L. Schneider, ed., Plenum Press, New York.
Goldstein, S. and Moerman, E.J., 1975, Heat-labile enzymes in Werner’s syndrome fibroblasts. Nature, 255: 159.
Goto, M., Horiuchi, Y., Tanimoto, K., Ishii, T., and Nakashima, H., 1978, Werner’s syndrome: analysis of 15 cases with a review of the Japanese literature. J. Amer. Geriatrics Soc., 26: 341–347.
Hayflick, L., 1981, The biology of human aging. Plastic Reconstru. Surg., 67: 536–550.
Hofecker, G., Skalicky, M., Kment, A., and Niedermuller, H., 1980, Models of the biological age of the rat. I. A factor model of age parameters. Mech. Ageing Develop., 14: 345–359.
Holliday, R., Porterfield, J.S., and Gibbs, D.D., 1974, Premature aging and occurrence of altered enzyme in Werner’s syndrome fibroblasts. Nature, 248: 762–763.
Hollingsworth, J.W., Hashizumi, A., and Jablon, S., 1965, Correlations between tests of aging in Hiroshima subjects—an attempt to define “physiological age.” Yale J. Biol. Med. 38: 11–26.
Ishii, T. and Hosoda, Y., 1975, Werner’s syndrome: autopsy report of one case, with a review of pathologic findings reported in the literature. J. Amer. Geriatrics Soc., 23: 145–154.
Ludwig, F.C. and Smoke, M.F., 1980, The measurement of biological age. Exp. Aging Res., 6: 497–522.
Martin, G.M., 1978, Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig. Art. Series 14 (1): 5–39.
Martin, G.M. Sprague, C.A., and Epstein, C.J., 1970, Replicative lifespan of cultivated human cells: effects of donor’s age, tissue and genotype. Lab. Invest., 23: 86–91.
Nakao, Y., Kishihara, M., Yoshimi, H., Inoue, Y., Tanaka, K., Sakamoto, N., Matsukura, S., Imura, H., Ichihashi, M., and Fujiwara, Y., 1978, Werner’s syndrome. In vivo and in vitro characteristics as a model of aging. Amer. J. Med., 65: 919–932.
Salk, D., 1982, Werner’s syndrome: a review of recent research
with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations. Hum. Genet., 62:1–15.
Salk, D., Au, K., Hoehn, H., and Martin, G.M., 1981, Cytogenetics of Werner’s syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet. Cell Genet.
-107.
Shock, N.W., 1981, Indices of functional age, In “Aging: A Challenge to Science and Society. Vol. 1, Biology,” D. Danon, N.W., Shock and M. Marois, eds., Oxford University Press, Oxford.
Walburg, H.E., Jr., 1975, Radiation-induced life shortening and premature aging. Advan. Radiat. Biol., 5: 145–179.
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© 1985 Plenum Press, New York
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Epstein, C.J. (1985). Werner’s Syndrome and Aging: A Reappraisal. In: Salk, D., Fujiwara, Y., Martin, G.M. (eds) Werner’s Syndrome and Human Aging. Advances in Experimental Medicine and Biology, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7853-2_9
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DOI: https://doi.org/10.1007/978-1-4684-7853-2_9
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