Abstract
Werner’s syndrome was first described by Werner (1904) as a mesodermal disorder clinically characterized by multifarious facets of premature senility. Numerous papers on Werner’s syndrome have since been written (Oppenheimer and Kugel 1934; Thannhauser 1945; Irwin and Ward 1953; Epstein et al., 1966). However, reports of a disorder of lipid metabolism and liver dysfunction were limited (Zucker-Franklin et al., 1968). The occurrence of Werner’s syndrome is relatively higher in Japan (Murata and Nakashima, 1982). To date, numerous clinical reports on this syndrome are to be found in the literature, but some of them are either incomplete or occasionally overlap. Only by cautious selection from among the publications in the medical literature, excluding incorrect cases, is it possible to reveal the clear-cut clinical features of this syndrome.
Supported in part by Grants-in-aid from the Ministry of Education, Science and Culture of Japan and grants from the Life Science Section of the Institute of Physical and Chemical Research and from Adult Disease Clinic Memorial Foundation, Tokyo
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References
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© 1985 Plenum Press, New York
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Murata, K., Nakashima, H. (1985). Clinical and Metabolic Studies on Werner’s Syndrome: With Special Reference to Disorders of Lipid and Liver Function. In: Salk, D., Fujiwara, Y., Martin, G.M. (eds) Werner’s Syndrome and Human Aging. Advances in Experimental Medicine and Biology, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7853-2_13
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DOI: https://doi.org/10.1007/978-1-4684-7853-2_13
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