Abstract
Recent studies (1, 2, 28–30, 33–35) have implicated ganglio-sides in the receptor recognition process for thyrotropin (TSH) and have led to the hypothesis (15–17, 19) that the TSH receptor is structurally and functionally related to receptors for other ligands which interact with gangliosides in vitro, i.e., cholera toxin, tetanus toxin, and interferon. This report summarizes the accumulated evidence which implicates both a glycoprotein (4, 38–40, 43) and a ganglioside in the structure and function of the TSH receptor. In the context of this symposium, particular attention will be addressed to the role of the ganglioside.
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ALOJ S.M., KOHN L.D., LEE G. and MELDOLESI M.G. (1977): The binding of thyrotropin to liposomes containing ganglio-sides. Biochem. Biophys. Res. Commun. 74, 1053–1059.
ALOJ S.M., LEE G., CONSIGLIO E., FORMISANO S., MINTON A.P. and KOHN L.D. (1979): Dansylated thyrotropin as a probe of hormone receptor interactions. J. Biol. Chem. 254, in press.
ALOJ S.M., LEE G., GROLLMAN E.F., BEGUINOT F., CONSIGLIO E. and KOHN L.D. (1979): Role of phospholipids in the structure and function of the thyrotropin receptor. J. Biol. Chem. 254, in press.
AMIR S.M., CARRAWAY T.F. Jr., KOHN L.D. and WINAND R.J. (1972): Thyrotropin binding to thyroid plasma membranes. J. Biol. Chem. 248, 4092–4100.
BENNETT V. and CUATRECASAS P. (1977): Membrane gangliosides and activation of adenylate cyclase, in “The Specificity and Action of Animal, Bacterial, and Plant Toxins”, CUATRECASAS P. and GREAVES M.F., Eds., Chapman and Hall (London), pp. 3–66.
CHANG E.H., GROLLMAN E.F., JAY F.T., LEE G., KOHN L.D. and FRIEDMAN R.M. (1978): Membrane alterations following interferon treatment, in “Human Interferon”, STINEBRING W.R. and CHAPPLE P.J., Eds., Plenum (New York), pp. 85–99.
FORMISANO S., LEE G., JOHNSON M.L., and EDELHOCH H. (1979): Critical micelle concentrations of gangliosides. Biochemistry 18, in press.
FRIEDMAN R.M. and KOHN L.D. (1976): Cholera toxin inhibits interferon action. Biochem. Biophys. Res. Commun. 70, 1078–1084.
GROLLMAN E.F., LEE G., AMBESI-IMPIOMBATO F.D., MELDOLESI M.F., ALOJ S.M., COON H.G., KABACK H.R. and KOHN L.D. (1977): Effects of thyrotropin on the thyroid cell membrane: hyper-polarization induced by hormone-receptor interaction. Proc. Natl. Acad. Sci. U.S.A. 74, 2352–2356.
GROLLMAN E.F., LEE G., RAMOS S., LAZO P.S., KABACK H.R., FRIEDMAN R.M. and KOHN L.D. (1978): Relationships of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state. Cancer Res. 38, 4172–4185.
HABIG W.H., GROLLMAN E.F., LEDLEY F.D., MELDOLESI M.F., ALOJ S.M., HARDEGREE M.C. and KOHN L.D. (1978): Tetanus toxin interactions with the thyroid: decreased toxin binding to membranes from a thyroid tumor with a thyrotropin receptor defect and in Vivostimulation of thyroid function. Endocrinology 102, 844–851.
HABIG W.H., HARDEGREE M.C., GROLLMAN E.F., LEE G., RAMOS S. KOHN L.D. (1979): Interaction of tetanus toxin with thyroid membranes, in Proceedings of the 5th International Tetanus Conference, Stockholm, Sweden, June 18–23, 1978, in press.
HILL I.R., LEVIN I.W., LAZO P.S. KOHN L.D. (1979): Effect of ganglioside and ganglioside-cholera toxin interactions on the vibrational Raman spectra of the bilayer lipid in dipalmitoyl phosphatidylcholine liposomes. Biochemistry 18, in press.
JAQUES L.W., BROWN E.B., BARRETT J.M., BREY W.S. and WELLNER W. (1977): Sialic acid: a calcium binding carbohydrate. J. Biol. Chem. 252, 4533–4538.
KOHN L.D. (1977): Characterization of the thyrotropin receptor and its involvement in Graves’ disease, in “Horizons in Biochemistry and Biophysics”, QUAGLIARIELLO E., Ed., Vol. 3, Addison-Wesley (Reading, Massachusetts ), pp. 123–163.
KOHN L.D. (1977): Relationships in the structure and function of cell surface receptors for glycoprotein hormones, bacterial toxins, and interferon, in “Annual Reports in Medicinal Chemistry”, CLARKE F.H., Ed., Vol. 12, Academic Press (New York), pp. 211–222.
KOHN L.D. (1978): Relationships in the structure and function of receptors for glycoprotein hormones, bacterial toxins, and interferon, in “Receptors and Recognition”, CUATRECASAS P. and GREAVES M.F., Eds., Series A, Vol. 5, Chapman and Hall (London), pp. 134–212.
KOHN L.D., FRIEDMAN R.M., HOLMES J.M. and LEE G. (1976): Use of thytrotopin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. Proc. Natl. Acad. Sci. U.S.A. 73, 3695–3699.
KOHN L.D., LEE G., GROLLMAN E.F., LEDLEY F.D., MULLIN B.R., FRIEDMAN R.M., MELDOLESI M.F. and ALOJ S.M. (1978): Membrane glycolipids and their relationship to the structure and function of cell surface receptors for glycoprotein hormones, bacterial toxins, and interferon, in “Cell Surface Carbohydrate Chemistry”, HARMAN R.E. ( Ed. ), Academic Press (New York), pp. 103–133.
KUROSKY A., MARKEL D.E., PETERSON J.W. and FITCH W.M. (1977): Primary structure of cholera toxin 13-chain: a glycoprotein hormone analog? Science 195, 299–301.
LAZO P.S., GROLLMAN E.F., LEE G. and FRIEDMAN R.M. (1978): Structure:function studies of the interferon receptor. Fed. Proc. 37, 1822.
LEDLEY F.D., LEE G., KOHN L.D., HABIG W.H. and HARDEGREE M.C. (1977): Tetanus toxin interactions with thyroid plasma membranes: implications for structure and function of tetanus toxin receptors and potential pathophysiological significance. J. Biol. Chem. 252, 4049–4055.
LEDLEY F.D., MULLIN B.R., LEE G., ALOJ S.M., FISHMAN P.H., HUNT L.T., DAYHOFF M.O. and KOHN L.D. (1976): Sequence similarity between cholera toxin and glycoprotein hormones: implications for structure activity relationship and mechanism of action. Biochem. Biophys. Res. Commun. 69, 852–859.
LEE G., ALOJ S.M., BRADY R.O. and KOHN L.D. (1976): The structure and function of glycoprotein hormone receptors: ganglioside interactions with human chorionic gonadotropin. Biochem. Biophys. Res. Commun. 73, 370–377.
LEE G., ALOJ S.M. and KOHN L.D. (1977): The structure and function of glycoprotein hormone receptors: ganglioside interactions with luteinizing hormone. Biochem. Biophys. Res. Commun. 77, 434–441.
LEE G., CONSIGLIO E., HABIG W.H., DYER S., HARDEGREE M.C. and KOHN L.D. (1978): Structure:function studies of receptors for thyrotropin and tetanus toxin: lipid modulation of effector binding to the glycoprotein receptor component. Biochem. Biophys. Res. Commun. 83, 313–320.
LEE G., CONSIGLIO E., HABIG W.H., DYER S., HARDEGREE M.C. and KOHN L.D. (1978): Structure:function studies of receptors for thyrotropin and tetanus toxin: lipid modulation of effector binding to the glycoprotein receptor component. Biochem. Biophys. Res. Commun. 83, 313–320.
LEE G., GROLLMAN E.F., ALOJ S.M., KOHN L.D. and WINAND R.J. (1977): Abnormal adenylate cyclase activity and altered gangliosides in thyroid cells from patients with Graves’ disease. Biochem. Biophys. Res. Commun. 77, 139–146.
MELDOLESI M.F., FISHMAN P.H., ALOJ S.M., KOHN L.D. and BRADY R.O. (1976): Relationship of gangliosides to the structure and function of thyrotropin receptors: their absence on plasma membranes of a thyroid tumor defective in thyrotropin activity. Proc. Natl. Acad. Sci. U.S.A. 73, 4060–4064.
MELDOLESI M.F., FISHMAN P.H., ALOJ S.M., LEDLEY F.D., LEE G., BRADLEY R.M., BRADY R.O. and KOHN L.D. (1977): Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes. Biochem. Biophys. Res. Commun. 75, 581–587.
MOSS J., FISHMAN P.H., RICHARDS R.L., ALVING C.R., VAUGHAN M. and BRADY R.O. (1976): Choleragen-mediated release of trapped glucose from liposomes containing ganglioside GM1• Proc. Natl. Acad. Sci. U.S.A. 73, 3480–3483.
MOSS J MANGANIELLO V.C. and VAUGHAN M. (1977): Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 73, 4424–4427.
MULLIN B.R., ALOJ S.M., FISHMAN P.H., LEE G., KOHN L.D. and BRADY R.O. (1976): Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes. Proc. Natl. Acad. Sci. U.S.A. 73, 1679–1683.
MULLIN B.R., FISHMAN P.H., LEE G., ALOJ S.M., LEDLEY F.D., WINAND R.J., KOHN L.D. and BRADY R.O. (1976): Thyrotropinganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc. Natl. Acad. Sci. U.S.A. 73, 842–846.
MULLIN B.R., PACUSZKA T., LEE G., KOHN L.D., BRADY R.O. and FISHMAN P.H. (1978): Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation. Science 199, 77–79.
POSS A., DELEERS M. and RUJSSCHERT J.M. (1978): Evidence for a specific interaction between GT1 ganglioside incorporated into bilayer membranes and thyrotropin binding. FEBS Letts. 86, 160–162.
POSS A., DELEERS M. and RUJSSCHERT J.M. (1978): Evidence for a specific interaction between GT1 ganglioside incorporated into bilayer membranes and thyrotropin binding. FEBS Letts. 86, 160–162.
TATE R.L., HOLMES J.M., KOHN L.D. and WINAND R.J. (1975): Characteristics of a solubilized thyrotropin receptor from bovine thyroid plasma membranes. J. Biol. Chem. 250, 6527–6533.
TATE R.L., SCHWARTZ H.I., HOLMES J.M., KOHN L.D. and WINAND R.J. (1975): Thyrotropin receptors in thyroid plasma membranes. J. Biol. Chem. 250, 6509–6515.
TATE R.L., WINAND R.J. and KOHN L.D. (1976): Solubilization and partial purification of the thyrotropin receptor, in “Thyroid Research”, ROBBINS J. and BRAVERMAN L., Eds., International Congress Series No. 378, Excerpta Medica (Amsterdam), pp. 57–60.
TOSTESON M.T. and TOSTESON D.C. (1978): Bilayers containing gangliosides develop channels when exposed to cholera toxin. Nature 275, 142–144.
WADELEUX P.A., ETIENNE-DECERF J., WINAND R.J. and KOHN L.D. (1978): Effects of thyrotropin on iodine metabolism of dog thyroid cells in tissue culture. Endocrinology 102, 889–902.
WINAND R.J. and KOHN L.D. (1975): Thyrotropin effects on thyroid cells in culture: effects of trypsin on the thyrotropin-medicated cyclic 3’:5’-AMP changes. J. Biol. Chem. 250, 6534–6540.
YOHE H.C., ROARK D.E. and ROSENBERG A. (1976): C20-Sphingosine as a determining factor in aggregation of gangliosides. J. Biol. Chem. 251, 7083–7087.
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Kohn, L.D. et al. (1980). Thyrotropin Receptors and Gangliosides. In: Svennerholm, L., Mandel, P., Dreyfus, H., Urban, PF. (eds) Structure and Function of Gangliosides. Advances in Experimental Medicine and Biology, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7844-0_43
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DOI: https://doi.org/10.1007/978-1-4684-7844-0_43
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