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The Specificity of β-Galactosidase in the Degradation of Gangliosides

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Structure and Function of Gangliosides

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 125))

Abstract

Degradation of gangliosides both in vivo and in vitro appears to proceed by sequential hydrolysis of the terminal carbohydrate residues, rather than by removal of oligosaccharides of two or more sugars or by initial de-acylation. These catabolic steps are catalyzed by lysosomal acidic glycosidases. Within the degradative pathways of known gangliosides, there are four compounds which possess a β-galactosyl residue at the non-reducing terminal.

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Author information

Author notes

  1. Dr. Harumi Tanaka

    Present address: Department of Child Neurology, National Musashi Research Institute for Mental and Nervous Diseases, Kodaira, Tokyo 187, Japan

Authors and Affiliations

  1. The Saul R. Korey Department of Neurology, Department of Neuroscience, and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, N.Y., 10461, USA

    Kunihiko Suzuki, Dr. Harumi Tanaka, Tatsuhiro Yamanaka & Olga Van Damme

Authors
  1. Kunihiko Suzuki
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  2. Dr. Harumi Tanaka
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  3. Tatsuhiro Yamanaka
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  4. Olga Van Damme
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Editor information

Editors and Affiliations

  1. Psychiatric Research Centre, Department of Neurochemistry, St. Jörgen Hospital, Göteborg, Sweden

    Lars Svennerholm

  2. C. N. R. S. Center for Neurochemistry, Strasbourg, France

    Paul Mandel , Henri Dreyfus  & Paul-Francis Urban ,  & 

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© 1980 Plenum Press, New York

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Suzuki, K., Tanaka, H., Yamanaka, T., Van Damme, O. (1980). The Specificity of β-Galactosidase in the Degradation of Gangliosides. In: Svennerholm, L., Mandel, P., Dreyfus, H., Urban, PF. (eds) Structure and Function of Gangliosides. Advances in Experimental Medicine and Biology, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7844-0_28

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  • DOI: https://doi.org/10.1007/978-1-4684-7844-0_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7846-4

  • Online ISBN: 978-1-4684-7844-0

  • eBook Packages: Springer Book Archive

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