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Inhibition of 5’lipoxygenase: Relevance to Inflammation

  • Chapter
Drugs Affecting Leukotrienes and Other Eicosanoid Pathways

Part of the book series: NATO ASI Series ((NSSA,volume 95))

Abstract

The mechanism by which non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and indomethacin, provide symptomatic relief for patients with inflammatory disease is generally recognised to be by inhibition of the formation of prostaglandins (PG’s) from arachidonic acid (AA). The evidence for the involvement of PG’s in inflammation is that elevated levels of PG’s have been detected in inflamed tissues and that PG’s, particularly PGE2, have properties which suggest that they could mediate oedema, erythema and hyperalgesia. In addition, therapeutic doses of NSAID reduce the concentrations of PG’s in inflamed tissues (for review see 1).

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  1. Department of Pharmacology and Prostaglandin Research, The Wellcome Research Laboratories Langley Court, Beckenham, Kent, BR3 3BS, UK

    R. M. J. Palmer & J. A. Salmon

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  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti  & G. C. Folco  & 

  3. University of Verona, Verona, Italy

    G. P. Velo

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Palmer, R.M.J., Salmon, J.A. (1985). Inhibition of 5’lipoxygenase: Relevance to Inflammation. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_24

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  • DOI: https://doi.org/10.1007/978-1-4684-7841-9_24

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